ArticleCurrent biology : CB2022
Retinal OFF ganglion cells allow detection of quantal shadows at starlight.
Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Loss of mitochondrial DNA helicase in retinal macroglia drives neovascular retinopathy.EMBO molecular medicine · 2026Article
- Divergent molecular and circuit mechanisms underlie light entrainment of retinal and suprachiasmatic nucleus circadian clocks.Cellular and molecular life sciences : CMLS · 2026Article
- Retinal Cx36 gap junctions in the inner and outer plexiform layers differentially control visual thresholds.iScience · 2026Article
- Graft-derived horizontal cells contribute to host-graft synapses in degenerated retinas after retinal organoid transplantation.Stem cell reports · 2025Article
- Altered proportions of retinal cell types and distinct visual codes in rodents occupying divergent ecological niches.Current biology : CB · 2025Article
- Transplantation of genome-edited retinal organoids restores some fundamental physiological functions coordinated with severely degenerated host retinas.Stem cell reports · 2025Article
- Temporal Transformation of the Rod Single-Photon Response in the Retinal Circuitry.Investigative ophthalmology & visual science · 2025Article
- Developmental control of rod number via a light-dependent retrograde pathway from intrinsically photosensitive retinal ganglion cells.Developmental cell · 2024Article
- Reconfiguration of the visual code and retinal cell type complement in closely related diurnal and nocturnal mice.bioRxiv : the preprint server for biology · 2024Article
- Primate retina trades single-photon detection for high-fidelity contrast encoding.Nature communications · 2024Article
- Vision: Life on the dark side.Current biology : CB · 2022Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perception of light in darkness requires no more than a handful of photons, and this remarkable behavioral performance can be directly linked to a particular retinal circuit-the retinal ON pathway. However, the neural limits of shadow detection in very dim light have remained unresolved. Here, we unravel the neural mechanisms that determine the sensitivity of mice (CBA/CaJ) to light decrements at the lowest light levels by measuring signals from the most sensitive ON and OFF retinal ganglion cell types and by correlating their signals with visually guided behavior. We show that mice can detect shadows when only a few photon absorptions are missing among thousands of rods. Behavioral detection of such "quantal" shadows relies on the retinal OFF pathway and is limited by noise and loss of single-photon signals in retinal processing. Thus, in the dim-light regime, light increments and decrements are encoded separately via the ON and OFF retinal pathways, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.