Evidence map›Paper›PMID 35609550›Full record

ReviewCurrent biology : CB2022

Natural behavior is the language of the brain.

Cory T Miller, David Gire, Kim Hoke, Alexander C Huk, Darcy Kelley, David A Leopold, Matthew C Smear, Frederic Theunissen, Michael Yartsev, Cristopher M Niell

Abstract readReview
In one paragraph

Review in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed.

  1. Article
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  12. Primate neuroethology: a new synthesis.Trends in cognitive sciences · 2026
    Review
  13. Article
  14. Visualizing and sonifying neurodata (ViSoND) for enhanced observation.bioRxiv : the preprint server for biology · 2026
    Article
  15. Article
  16. Active gaze behavior organizes V1 activity in freely-moving marmosets.bioRxiv : the preprint server for biology · 2026
    Article
  17. Saccade-related LFP power transients in the primate amygdala and hippocampus linked to the perception of social status.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  18. Article
  19. Article
  20. Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cory T MillerCortical Systems and Behavior Laboratory, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92039, USA. Electronic address: corymiller@ucsd.edu.
David GireDepartment of Psychology, University of Washington, Guthrie Hall, Seattle, WA 98105, USA.
Kim HokeDepartment of Biology, Colorado State University, 1878 Campus Delivery, Fort Collins, CO 80523, USA.
Alexander C HukCenter for Perceptual Systems, Departments of Neuroscience and Psychology, University of Texas at Austin, 116 Inner Campus Drive, Austin, TX 78712, USA.
Darcy KelleyDepartment of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA.
David A LeopoldSection of Cognitive Neurophysiology and Imaging, National Institute of Mental Health, 49 Convent Drive, Bethesda, MD 20892, USA.
Matthew C SmearDepartment of Psychology and Institute of Neuroscience, University of Oregon, 1227 University Street, Eugene, OR 97403, USA.
Frederic TheunissenDepartment of Psychology, University of California Berkeley, 2121 Berkeley Way, Berkeley, CA 94720, USA.
Michael YartsevDepartment of Bioengineering, University of California Berkeley, 306 Stanley Hall, Berkeley, CA 94720, USA.
Cristopher M NiellDepartment of Biology and Institute of Neuroscience, University of Oregon, 222 Huestis Hall, Eugene, OR 97403, USA. Electronic address: cniell@uoregon.edu.

Funding

Visual Adaptation and Neuronal SelectivityZIAMH002898 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEOPOLD, DAVID A · 2009 to 2025
$13.6M
Neural circuit computations for visual motion during natural primate behaviorsUF1NS116377 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI CAUWENBERGHS, GERT, CORMACK, LAWRENCE KEVIN · 2020 to 2020
$3.3M
Spatial exploration and navigation in the primate hippocampusRF1NS118457 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLER, CORY T, ZHANG, KECHEN · 2020 to 2020
$2.0M
NINDS NIH HHS RF1 NS118457NINDS NIH HHS UF1 NS116377
6 · The paper itself

Abstract

The breadth and complexity of natural behaviors inspires awe. Understanding how our perceptions, actions, and internal thoughts arise from evolved circuits in the brain has motivated neuroscientists for generations. Researchers have traditionally approached this question by focusing on stereotyped behaviors, either natural or trained, in a limited number of model species. This approach has allowed for the isolation and systematic study of specific brain operations, which has greatly advanced our understanding of the circuits involved. At the same time, the emphasis on experimental reductionism has left most aspects of the natural behaviors that have shaped the evolution of the brain largely unexplored. However, emerging technologies and analytical tools make it possible to comprehensively link natural behaviors to neural activity across a broad range of ethological contexts and timescales, heralding new modes of neuroscience focused on natural behaviors. Here we describe a three-part roadmap that aims to leverage the wealth of behaviors in their naturally occurring distributions, linking their variance with that of underlying neural processes to understand how the brain is able to successfully navigate the everyday challenges of animals' social and ecological landscapes. To achieve this aim, experimenters must harness one challenge faced by all neurobiological systems, namely variability, in order to gain new insights into the language of the brain.

Indexed as

BrainNeurosciencesAnimalsLanguage

Identifiers

PMID35609550
PMCPMC10082559

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.