Evidence map›Paper›PMID 35609545›Full record

ArticleCurrent biology : CB2022

Ribosome collisions: New ways to initiate ribosome rescue.

Stephanie L Leedom, Kenneth C Keiler

Abstract readComment
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Translation factors that keep the ribosome Pro-active.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Stephanie L LeedomDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Kenneth C KeilerDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: kkeiler@psu.edu.

Funding

Physiology of ribosome rescue in bacteriaR01GM121650 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI KEILER, KENNETH C · 2017 to 2025
$3.8M
Targeting trans-translation to kill M. tuberculosis non-replicating persister cellsR01AI158706 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI ANTHONY D BAUGHN, Kenneth C Keiler · 2022 to 2026
$3.4M
NIAID NIH HHS R01 AI158706NIGMS NIH HHS R01 GM121650
6 · The paper itself

Abstract

When ribosomes collide while translating the same mRNA, a MutS-like protein can pry apart the leading ribosome and a nuclease can cut the mRNA between the collided ribosomes to initiate ribosome rescue and recycling.

Indexed as

Protein BiosynthesisRibosomesHumansProteinsRNA, MessengerProteinsRNA, Messenger

Identifiers

PMID35609545
PMCPMC9247869

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.