ArticlePloS one2022
Anxiety, depression, and substance experimentation in childhood.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07074860 (Clinical Screening and Peer Interventions to Prevent Substance Use in At-Risk Adolescents), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Screening and Peer Interventions to Prevent Substance Use in At-Risk Adolescents
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unhealthy behaviors associated with mental health disorders: a systematic comparative review of diet quality, sedentary behavior, and cannabis and tobacco use.Frontiers in public health · 2023Pooled it
- Association between viewing more media war content and higher intention to use cannabis in adolescents: the indirect effect of post-traumatic stress.Substance abuse treatment, prevention, and policy · 2026Article
- Depressive Symptoms and Adaptive Risk Decision-Making in Adolescents: Evidence from the Balloon Analogue Risk Task.Research on child and adolescent psychopathology · 2026Article
- Cost-Effectiveness of Stepped Care Versus Stratified Care for Pediatric Anxiety Disorders: A Pilot Evaluation in Routine Care.Child psychiatry and human development · 2026Article
- Social Media Use Trajectories and Substance Use Experimentation: A Prospective Cohort Study.The American journal of psychiatry · 2026Article
- Clinical screening and peer interventions to prevent substance use in at-risk adolescents: A longitudinal single-arm trial protocol.Contemporary clinical trials communications · 2026Article
- Impulse Control in Focus: Rethinking Impulsivity in Youth With Attention-Deficit/Hyperactivity Disorder.JAACAP open · 2026Article
- Validation of CBCL depression scores of adolescents in three independent datasets.JCPP advances · 2025Article
- Early life stress and pubertal predictors of subsequent substance use in a national diverse sample of adolescents: Sex and substance type matter.Drug and alcohol dependence · 2025Article
- Insights into Overlapping Brain Networks for Anxiety and Alcohol Use Disorders.Current topics in behavioral neurosciences · 2025Review
- The ABCD and HBCD Studies: Longitudinal Studies to Inform Prevention Science.Focus (American Psychiatric Publishing) · 2024Review
- Risk-taking and self-harm behaviors as markers of adolescent borderline personality disorder.European child & adolescent psychiatry · 2024Article
- Addressing cortex dysregulation in youth through brain health check coaching and prophylactic brain development.INNOSC theranostics & pharmacological sciences · 2024Article
- Sleep Apnea and Substance Use Disorders Associated with Co-Occurrence of Anxiety Disorder and Depression among U.S. Adults: Findings from the NSDUH 2008-2014.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Previous research has demonstrated that adults with comorbid depressive and anxiety disorders are significantly more likely to show pathological use of drugs or alcohol. Few studies, however, have examined associations of this type in children. A better understanding of the relationships between affective disorders and substance experimentation in childhood could help clarify the complex ways in which pathological substance use symptoms develop early in life. The present study included 11,785 children (Mage = 9.9) participating in the Adolescent Brain Cognitive Development (ABCD) study. Depressive and anxiety disorder diagnoses were evaluated as concurrent predictors of experimentation with alcohol and tobacco. A series of linear regressions revealed that children with either depressive or anxiety disorders were significantly more likely to experiment with alcohol or tobacco. However, children with both depressive and anxiety diagnoses were not more likely to experiment than children without a diagnosis. These results suggest that anxiety or depressive diagnoses in childhood may be associated with a greater likelihood of substance experimentation, but severe psychological distress may suppress these effects.
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Registered trials
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