Evidence map›Paper›PMID 35608955›Full record

ArticleImmunology and cell biology2022

Differences in H3K4me3 and chromatin accessibility contribute to altered T-cell receptor signaling in neonatal naïve CD4 T cells.

Jennifer R Bermick, Priya Issuree, Aaron denDekker, Katherine A Gallagher, Donna Santillan, Steven Kunkel, Nicholas Lukacs, Matthew Schaller

Open access · hybridAbstract read
In one paragraph

Article in Immunology and cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. A side-by-side comparison of commercial CUT&RUN kits.Journal of biomolecular techniques : JBT · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jennifer R BermickDivision of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-0245-946X
Priya IssureeDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Aaron denDekkerDepartment of Vascular Surgery, Michigan Medicine, Ann Arbor, MI, USA.
Katherine A GallagherDepartment of Vascular Surgery, Michigan Medicine, Ann Arbor, MI, USA.
Donna SantillanDepartment of Obstetrics and Gynecology, University of Iowa, Iowa City, IA, USA.
Steven KunkelDepartment of Pathology, Michigan Medicine, Ann Arbor, MI, USA.
Nicholas LukacsDepartment of Pathology, Michigan Medicine, Ann Arbor, MI, USA.
Matthew SchallerDepartment of Pathology, Michigan Medicine, Ann Arbor, MI, USA.
Michigan Medicine · USUniversity of Iowa · USUniversity of Florida · US

Funding

The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
Understanding the role of histone3 lysine4 trimethylation in neontal innate immune development under normal and inflammatory conditionsR01AI141673 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERMICK, JENNIFER · 2020 to 2024
$1.9M
Vasopressin and Preeclampsia: Early Mechanisms for PreventionR01HD089940 · NICHD · UNIVERSITY OF IOWA · PI SANTILLAN, MARK K · 2019 to 2023
$1.9M
NCATS NIH HHS UL1 TR002537NIAID NIH HHS R01 AI141673NICHD NIH HHS R01 HD089940
6 · The paper itself

Abstract

Neonatal CD4

Indexed as

CD4-Positive T-LymphocytesChromatinAdultHistonesHumansInfant, NewbornLymphocyte ActivationReceptors, Antigen, T-CellTumor Necrosis Factor-alphaChromatinhistone H3 trimethyl Lys4HistonesReceptors, Antigen, T-CellTumor Necrosis Factor-alphaATAC-seqChIP-seqepigeneticsneonateT cellT-cell receptor

Identifiers

PMID35608955
PMCPMC9357221
OpenAlexW4281387056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.