Evidence map›Paper›PMID 35608899›Full record

ArticleeLife2022

A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian.

Eleni Chrysostomou, Hakima Flici, Sebastian G Gornik, Miguel Salinas-Saavedra, James M Gahan, Emma T McMahon, Kerry Thompson, Shirley Hanley, Michelle Kilcoyne, Christine E Schnitzler and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
20.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

  1. A gene-agnostic FACS technique to isolate stem cells inbioRxiv : the preprint server for biology · 2026
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  6. An updated and spatially validated somatic single-cell atlas ofbioRxiv : the preprint server for biology · 2025
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  13. A wound-induced differentiation trajectory for neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. The genome of the colonial hydroidGenome research · 2024
    Article
  15. Article
  16. Article
  17. SABER-FISH in Hydractinia.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Eleni ChrysostomouCentre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland.ORCID https://orcid.org/0000-0003-2455-6321
Hakima FliciCentre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland.
Sebastian G GornikCentre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland.ORCID https://orcid.org/0000-0002-8026-1336
Miguel Salinas-SaavedraCentre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland.ORCID https://orcid.org/0000-0002-1598-9881
James M GahanCentre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland.
Emma T McMahonCentre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland.ORCID https://orcid.org/0000-0003-3933-8853
Kerry ThompsonCentre for Microscopy and Imaging, Discipline of Anatomy, National University of Ireland, Galway, Galway, Ireland.ORCID https://orcid.org/0000-0003-2721-8977
Shirley HanleyNational Centre for Biomedical Engineering Science, National University of Ireland, Galway, Galway, Ireland.
Michelle KilcoyneCarbohydrate Signalling Group, Microbiology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland.
Christine E SchnitzlerWhitney Laboratory for Marine Bioscience, University of Florida, St. Augustine, Florida, United States.ORCID https://orcid.org/0000-0002-5001-6524
Paul GonzalezComputational and Statistical Genomics Branch, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States.
Andreas D BaxevanisComputational and Statistical Genomics Branch, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States.ORCID https://orcid.org/0000-0002-5370-0014
Uri FrankCentre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland.ORCID https://orcid.org/0000-0003-2094-6381
Ollscoil na Gaillimhe – University of Galway · IENational Institutes of Health · USWhitney Museum of American Art · US

Funding

Phylogenomic Studies on the Evolution of Morphological ComplexityZIAHG000140 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAXEVANIS, ANDREAS · 2009 to 2025
$11.4M
Characterizing the molecular regulators of stem cell populations during homeostasis and regeneration in Hydractinia, an emerging cnidarianresearch organism; Administrative SupplementsR35GM138156 · NIGMS · UNIVERSITY OF FLORIDA · PI SCHNITZLER, CHRISTINE · 2020 to 2024
$1.9M
Intramural NIH HHS ZIA HG000140NIGMS NIH HHS R35 GM138156Wellcome TrustWellcome Trust 210722/Z/18/Z
6 · The paper itself

Abstract

Neurogenesis is the generation of neurons from stem cells, a process that is regulated by SoxB transcription factors (TFs) in many animals. Although the roles of these TFs are well understood in bilaterians, how their neural function evolved is unclear. Here, we use

Indexed as

CnidariaAnimalsNervous SystemNeurogenesisNeuronsStem CellsCnidariadevelopmentdevelopmental biologyevolutionHydractinianeurogenesisneuroscienceregenerationstem cells

Identifiers

PMID35608899
PMCPMC9173746
OpenAlexW4282918051

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.