ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022
The Italian tremor Network (TITAN): rationale, design and preliminary findings.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- AI Video Analysis in Parkinson's Disease: A Systematic Review of the Most Accurate Computer Vision Tools for Diagnosis, Symptom Monitoring, and Therapy Management.Sensors (Basel, Switzerland) · 2025Pooled it
- Machine learning and wearable sensors for automated Parkinson's disease diagnosis aid: a systematic review.Journal of neurology · 2024Pooled it
- Is There a Relationship Between Movement and Sleep Disturbances in Essential Tremor?Brain sciences · 2026Article
- Neuropsychiatric, stress-related symptoms and essential tremor clinical variability.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- The Cerebellar Cognitive Affective Syndrome in Essential Tremor Plus.Cerebellum (London, England) · 2025Article
- Serum glial fibrillary acidic protein is elevated in early-stage late-onset essential tremor and associated with tremor progression.Journal of neural transmission (Vienna, Austria : 1996) · 2025Observational
- Validity of tremor analysis using smartphone compatible computer vision frameworks.Scientific reports · 2025Article
- The "Writing on the Wall Maneuver" Reveals the Dystonic Nature of Primary Writing Tremor.Movement disorders clinical practice · 2025Article
- Biochemical Sensors for Personalized Therapy in Parkinson's Disease: Where We Stand.Journal of clinical medicine · 2024Review
- Clinical and kinematic characterization of parkinsonian soft signs in essential tremor.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Comparing Essential Tremor with and without Soft Dystonic Signs and Tremor Combined with Dystonia: The TITAN Study.Movement disorders clinical practice · 2024Article
- Assessing ChatGPT Ability to Answer Frequently Asked Questions About Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Combined cortical thickness and blink reflex recovery cycle to differentiate essential tremor with and without resting tremor.Frontiers in neurology · 2024Article
- Clinical Management of Movement Disorders.Journal of clinical medicine · 2023Article
- Age and Sex Affect Essential Tremor (ET) Plus: Clinical Heterogeneity in ET Based on the National Survey in China.Aging and disease · 2023Article
- Diagnosis Versus Classification of Essential Tremor: A Research Perspective.Journal of movement disorders · 2023Article
- Longitudinal study of clinical and neurophysiological features in essential tremor.European journal of neurology · 2023Article
- Instagram for Measuring Tremor: Who Holds the Camera?Movement disorders clinical practice · 2023Article
- May Bradykinesia Features Aid in Distinguishing Parkinson's Disease, Essential Tremor, And Healthy Elderly Individuals?Journal of Parkinson's disease · 2023Article
- Clinical correlates of "pure" essential tremor: the TITAN study.Frontiers in neurology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
33 authors at 18 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe recently released classification has revised the nosology of tremor, defining essential tremor (ET) as a syndrome and fueling an enlightened debate about some newly conceptualized entities such as ET-plus. As a result, precise information of demographics, clinical features, and about the natural history of these conditions are lacking.
methodsThe ITAlian tremor Network (TITAN) is a multicenter data collection platform, the aim of which is to prospectively assess, according to a standardized protocol, the phenomenology and natural history of tremor syndromes.
resultsIn the first year of activity, 679 patients have been recruited. The frequency of tremor syndromes varied from 32% of ET and 41% of ET-plus to less than 3% of rare forms, including focal tremors (2.30%), task-specific tremors (1.38%), isolated rest tremor (0.61%), and orthostatic tremor (0.61%). Patients with ET-plus were older and had a higher age at onset than ET, but a shorter disease duration, which might suggest that ET-plus is not a disease stage of ET. Familial aggregation of tremor and movement disorders was present in up to 60% of ET cases and in about 40% of patients with tremor combined with dystonia. The body site of tremor onset was different between tremor syndromes, with head tremor being most commonly, but not uniquely, associated with dystonia.
conclusionsThe TITAN study is anticipated to provide clinically relevant prospective information about the clinical correlates of different tremor syndromes and their specific outcomes and might serve as a basis for future etiological, pathophysiological, and therapeutic research.
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