Evidence map›Paper›PMID 35608694›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

Comparative randomized trial study about the efficacy of photobiomodulation and curcumin antimicrobial photodynamic therapy as a coadjuvant treatment of oral mucositis in oncologic patients: antimicrobial, analgesic, and degree alteration effect.

Rita de Cássia Dias Viana Andrade, Thaís Azevedo Reis, Luciano Pereira Rosa, Gabriel Pinto de Oliveira Santos, Francine da CristinaSilva

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rita de Cássia Dias Viana AndradeCruzeiro Do Sul University, Paulista Avenue, 1415 Centro, São Paulo, São Paulo, 01311-925, Brazil.
Thaís Azevedo ReisMultidisciplinary Health Institute, Federal University of Bahia, Vitória da Conquista, Rio de Contas Street, 58 Candeias, Bahia, 450029-094, Brazil. tazevedo011@gmail.com.ORCID http://orcid.org/0000-0002-9929-5763
Luciano Pereira RosaMultidisciplinary Health Institute, Federal University of Bahia, Vitória da Conquista, Rio de Contas Street, 58 Candeias, Bahia, 450029-094, Brazil.
Gabriel Pinto de Oliveira SantosMultidisciplinary Health Institute, Federal University of Bahia, Vitória da Conquista, Rio de Contas Street, 58 Candeias, Bahia, 450029-094, Brazil.
Francine da CristinaSilvaMultidisciplinary Health Institute, Federal University of Bahia, Vitória da Conquista, Rio de Contas Street, 58 Candeias, Bahia, 450029-094, Brazil.
Universidade Federal da Bahia · BRUniversidade Cruzeiro do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAs conventional treatments currently available for mucositis are not considerably effective, there is a need to implement an adjuvant protocol for the treatment of oral mucositis in patients undergoing radiotherapy and chemotherapy. PURPOSE: To evaluate the effect of photobiomodulation (PBM) and antimicrobial photodynamic therapy (aPDT) mediated by curcumin and blue LED as an adjunct treatment of oral mucositis for oncology patients using chemotherapy and/or radiotherapy.

methodsClinical, randomized study, in a single location, in an oncology service of a general hospital, with a total of 30 patients (over 18 years old) with stable oral mucosa lesions in the process of chemotherapy and/or radiotherapy. The patients were divided into 3 groups: control group (treated with nystatin), PBM group (treated with low-level laser therapy), and the aPDT group (treated with 450-nm blue LED and curcumin photosensitizer).

resultsThe results showed, by means of intra-group comparisons, that the two experimental treatments promoted yeast reduction of the genus Candida in the last two evaluations (21 days and 30 days), but not in the first two evaluations (7 days and 14 days). The intra-group comparisons showed that the control and aPDT group showed a significant difference in the degree of mucositis over the four evaluations performed, with the results pointing out that the mucositis worsened in the control group from the 14th day, while reduced in the aPDT group from the 21st day of treatment.

conclusionA reduction in the degree of mucositis and pain score was observed in the PBM and aPDT groups, with the aPDT group standing out when presenting early clinical improvement in relation to the PBM group and the control group, thus emphasizing its effectiveness within the desired aspects. Regarding the antimicrobial effect, aPDT showed a greater reduction of yeasts of the genus Candida in the tested parameters.

Indexed as

Anti-Infective AgentsCurcuminMucositisPhotochemotherapyStomatitisAdolescentAnalgesicsAnti-Bacterial AgentsHumansAnalgesicsAnti-Bacterial AgentsAnti-Infective AgentsCurcuminCancerCurcuminOral mucositisPhotobiomodulationPhotodynamic therapy

Identifiers

PMID35608694
OpenAlexW4282928072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.