ArticleNeuroradiology2022
Enhancement of cranial nerves in Lyme neuroborreliosis: incidence and correlation with clinical symptoms and prognosis.
Article in Neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Serum neurofilament light chain associates with symptom burden in Lyme neuroborreliosis patients: a longitudinal cohort study from Norway.Journal of neurology · 2024Trial
- Biomarkers of Lyme neuroborreliosis: a systematic review.Infection · 2026Review
- Lyme Neuroborreliosis Presenting As Diplopia and Syndrome of Inappropriate Antidiuretic Hormone Secretion.Cureus · 2026Article
- Findings on Magnetic Resonance Imaging in Neuroborreliosis-A Nationwide Cohort Study.European journal of neurology · 2026Article
- A retrospective study on differences in neuroborreliosis symptoms, signs and findings between adults and children.BMC infectious diseases · 2026Article
- Letter to the Editor: Clinical Characteristics in Danish Children and Adults Diagnosed With Neuroborreliosis: A Retrospective Study From January 2016 to January 2024.European journal of neurology · 2025Article
- Clinical Characteristics in Danish Children and Adults Diagnosed With Neuroborreliosis: A Retrospective Study From January 2016 to January 2024.European journal of neurology · 2025Article
- Isolated Abducens Nerve Palsy in an Adolescent With Confounding Multisystem Serology: A Case Report and Diagnostic Review.Case reports in pediatrics · 2025Article
- Are white matter hyperintensities associated with neuroborreliosis? The answer is twofold.Neuroradiology · 2025Article
- Brain MRI findings in patients with post COVID-19 condition: frequency and longitudinal changes in a nationwide cohort study.Frontiers in neurology · 2025Article
- Cerebrospinal Fluid Cytology in Lyme Neuroborreliosis Revisited-Role of Neutrophilic Granulocytes: A Retrospective Single-Center Study.Journal of clinical medicine · 2024Article
- Diagnostic Challenges of Lyme Neuroborreliosis in Inpatient Neurology: A Case Series.The Neurohospitalist · 2024Article
- Dynamic contrast-enhanced MRI shows altered blood-brain barrier function of deep gray matter structures in neuroborreliosis: a case-control study.European radiology experimental · 2023Article
- Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis.Journal of neurology · 2023Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
purposeSymptoms of cranial neuritis are a common presentation of Lyme neuroborreliosis (LNB). Imaging studies are scarce and report contradictory low prevalence of enhancement compared to clinical studies of cranial neuropathy. We hypothesized that MRI enhancement of cranial nerves in LNB is underreported, and aimed to assess the prevalence and clinical impact of cranial nerve enhancement in early LNB.
methodsIn this prospective, longitudinal cohort study, 69 patients with acute LNB were examined with MRI of the brain. Enhancement of cranial nerves III-XII was rated. MRI enhancement was correlated to clinical findings of neuropathy in the acute phase and after 6 months.
resultsThirty-nine of 69 patients (57%) had pathological cranial nerve enhancement. Facial and oculomotor nerves were most frequently affected. There was a strong correlation between enhancement in the distal internal auditory canal and parotid segments of the facial nerve and degree of facial palsy (gamma = 0.95, p < .01, and gamma = 0.93, p < .01), despite that 19/37 nerves with mild-moderate enhancement in the distal internal auditory canal segment showed no clinically evident palsy. Oculomotor and abducens nerve enhancement did not correlate with eye movement palsy (gamma = 1.00 and 0.97, p = .31 for both). Sixteen of 17 patients with oculomotor and/or abducens nerve enhancement had no evident eye movement palsy.
conclusionsMRI cranial nerve enhancement is common in LNB patients, but it can be clinically occult. Facial and oculomotor nerves are most often affected. Enhancement of the facial nerve distal internal auditory canal and parotid segments correlate with degree of facial palsy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.