Evidence map›Paper›PMID 35608628›Full record

ArticleEmerging infectious diseases2022

Geographic Origin and Vertical Transmission of Leishmania infantum Parasites in Hunting Hounds, United States.

Susanne U Franssen, Mandy J Sanders, Matt Berriman, Christine A Petersen, James A Cotton

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  6. Fatal babesiosis in a free-ranging iberian wolf co-infected withInternational journal for parasitology. Parasites and wildlife · 2025
    Article
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  11. Article
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  13. Possibility ofCurrent tropical medicine reports · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Susanne U Franssen
Mandy J Sanders
Matt Berriman
Christine A Petersen
James A Cotton
University of Iowa · USWellcome Sanger Institute · GBLudwig-Maximilians-Universität München · DE

Funding

Epidemic modeling framework for complex, multi-species disease processesR01TW010500 · FIC · UNIVERSITY OF IOWA · PI OLESON, JACOB, PETERSEN, CHRISTINE A · 2016 to 2020
$2.4M
FIC NIH HHS R01 TW010500Wellcome Trust
6 · The paper itself

Abstract

Vertical transmission of leishmaniasis is common but is difficult to study against the background of pervasive vector transmission. We present genomic data from dogs in the United States infected with Leishmania infantum parasites; these infections have persisted in the apparent absence of vector transmission. We demonstrate that these parasites were introduced from the Old World separately and more recently than L. infantum from South America. The parasite population shows unusual genetics consistent with a lack of meiosis: a high level of heterozygous sites shared across all isolates and no decrease in linkage with genomic distance between variants. Our data confirm that this parasite population has been evolving with little or no sexual reproduction. This demonstration of vertical transmission has profound implications for the population genetics of Leishmania parasites. When investigating transmission in complex natural settings, considering vertical transmission alongside vector transmission is vital.

Indexed as

Dog DiseasesLeishmania infantumLeishmaniasis, VisceralParasitesAnimalsDogsInfectious Disease Transmission, VerticalUnited StatesWorking Dogsclonal evolutiongenomicshunting houndsLeishmania infantumleishmaniasisparasitesUnited Statesvertical transmission

Identifiers

PMID35608628
PMCPMC9155895
OpenAlexW4280576357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.