ArticleEmerging infectious diseases2022
Effects of Acute Dengue Infection on Sperm and Virus Clearance in Body Fluids of Men.
Article in Emerging infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03612609 (Pilot Study to Detect DENGUE Virus in Sperm.), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study to Detect DENGUE Virus in Sperm.
Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Mosquito-borne viruses and male infertility: Zika was just the beginning - the impact of dengue on sperm DNA integrity.Annals of medicine and surgery (2012) · 2026Article
- Severe fever with thrombocytopenia syndrome virus infection of the male reproductive tract induces pathology and inflammation.Nature microbiology · 2026Article
- Dengue virus and infertility: effects on reproductive health and outcomes.JBRA assisted reproduction · 2025Review
- Dengue Virus Dynamic and Persistence in Body Fluids of Infected Patients in Italy, 2018-2023.Journal of medical virology · 2025Article
- Immune Regulation in the Testis and Epididymis.Advances in experimental medicine and biology · 2025Review
- Correlation between viral infections in male semen and infertility: a literature review.Virology journal · 2024Review
- An Update on the Entomology, Virology, Pathogenesis, and Epidemiology Status of West Nile and Dengue Viruses in Europe (2018-2023).Tropical medicine and infectious disease · 2024Review
- COVID-19 vaccine and its effect on sperm.Reproduction & fertility · 2023Article
- Semen and viruses: significance during the transmission of infections.Journal of assisted reproduction and genetics · 2022Article
- Autoimmune hepatitis triggered by COVID-19 vaccination: correspondence.Clinical journal of gastroenterology · 2022Article
- Atypical Cutaneous Manifestation-Scrotal Dermatitis and Epididymo-Orchitis in Two Cases with Dengue Fever.Indian dermatology online journalArticle
- Monkeypox and Male Fertility: Is There Any Looming Danger?Journal of reproduction & infertilityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effects of dengue virus (DENV) on semen using samples collected 7, 15, 30, 60, and 90 days after symptom onset from 10 infected volunteers on Réunion Island. We assessed characteristics of semen and reproductive hormones and isolated motile spermatozoa from semen. We assayed semen for DENV using reverse transcription PCR and searched for DENV RNA by virus isolation in Vero E6 cell cultures. Four volunteers had >1 DENV RNA-positive semen samples; 2 volunteers had DENV RNA-positive semen at day 15 and 1 at day 30. No motile sperm were DENV positive. After exposure to positive semen, few Vero E6 cells stained positive for DENV antigens, indicating low levels of replicative virus. We found DENV had shorter duration in semen than in blood. These findings support the possibilities that DENV is sexually transmissible for a short period after acute dengue illness and that acute dengue induces reversible alterations in sperm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.