Evidence map›Paper›PMID 35608456›Full record

ArticleScience (New York, N.Y.)2022

Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness.

Fritz Obermeyer, Martin Jankowiak, Nikolaos Barkas, Stephen F Schaffner, Jesse D Pyle, Leonid Yurkovetskiy, Matteo Bosso, Daniel J Park, Mehrtash Babadi, Bronwyn L MacInnis and 3 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 216 papers.

0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed
35.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

216 citing papers in PubMed, 339 citations in OpenAlex.

  1. Trial
  2. Variant-Specific Viral Kinetics in Acute COVID-19.The Journal of infectious diseases · 2023
    Trial
  3. Review
  4. Review
  5. Article
  6. Direct estimation of genotype fitness from time series.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Integrated framework to study genomic surveillance of selective sweeps in multivariants dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

156 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Fritz ObermeyerBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-2850-4991
Martin JankowiakBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-1724-0436
Nikolaos BarkasBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-4675-0718
Stephen F SchaffnerBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-6699-3568
Jesse D PyleBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-0115-9921
Leonid YurkovetskiyProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.ORCID 0000-0001-5078-493X
Matteo BossoProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.ORCID 0000-0001-9344-9963
Daniel J ParkBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-7226-7781
Mehrtash BabadiBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-1829-8397
Bronwyn L MacInnisBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-0082-968X
Jeremy LubanBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-8101-5455
Pardis C Sabeti *Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-9843-1890
Jacob E Lemieux *Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-2758-4005
Broad Institute · USUniversity of Massachusetts Chan Medical School · US

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI NEAFSEY, DANIEL E · 2014 to 2024
$66.5M
The HUSH complex in HIV-1 latencyR37AI147868 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI JEREMY LUBAN · 2019 to 2026
$6.4M
NIAID NIH HHS R37 AI147868NIAID NIH HHS U19 AI110818
6 · The paper itself

Abstract

Repeated emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increased fitness underscores the value of rapid detection and characterization of new lineages. We have developed PyR

Indexed as

COVID-19Genetic FitnessSARS-CoV-2Bayes TheoremGenome, ViralHumansMutationRegression AnalysisSpike Glycoprotein, CoronavirusSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID35608456
PMCPMC9161372
OpenAlexW4281383093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.