Evidence map›Paper›PMID 35608347›Full record

ArticleJournal of virology2022

DLK-Dependent Biphasic Reactivation of Herpes Simplex Virus Latency Established in the Absence of Antivirals.

Sara Dochnal, Husain Y Merchant, Austin R Schinlever, Aleksandra Babnis, Daniel P Depledge, Angus C Wilson, Anna R Cliffe

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

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  5. Co-option of mitochondrial nucleic acid-sensing pathways by HSV-1 UL12.5 for reactivation from latent infection.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  17. Journal of virology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sara DochnalDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.
Husain Y MerchantDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.
Austin R SchinleverDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.
Aleksandra BabnisDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.
Daniel P DepledgeDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.ORCID 0000-0002-4292-0599
Angus C WilsonDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.ORCID 0000-0002-5016-4164
Anna R CliffeDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0003-1136-5171
University of Virginia · USNew York University · US

Funding

TRAINING IN CELL AND MOLECULAR BIOLOGYT32GM008136 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI STUKENBERG, P. TODD · 1985 to 2020
$8.5M
Virus Host Interactions that Regulate Translation in Cells Infected with HSV-1R01AI073898 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MOHR, IAN J · 2008 to 2020
$5.0M
EPITRANSCRIPTOMIC REGULATION OF CYTOMEGALOVIRUS INFECTIONR01AI152543 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DEPLEDGE, DANIEL PEARCE, MOHR, IAN J · 2020 to 2025
$2.7M
Cell stress-mediated changes in the Herpes simplex virus type 1 chromatin structure during reactivation from latent infectionR01NS105630 · NINDS · UNIVERSITY OF VIRGINIA · PI CLIFFE, ANNA RUTH · 2018 to 2022
$1.8M
Viral manipulation of neuronal microRNAs to maintain trophic support and HSV latencyR21AI147163 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WILSON, ANGUS C · 2019 to 2020
$475k
Modeling herpes simplex virus latency in human neuronsR21AI130618 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WILSON, ANGUS C · 2018 to 2019
$466k
IFN-dependent repression of HSV latency by PML-nuclear bodiesR21AI151340 · NIAID · UNIVERSITY OF VIRGINIA · PI CLIFFE, ANNA RUTH · 2020 to 2021
$444k
Epigenomic profiling of neurotrophic herpesvirus chromatin by controlled antibody-targeted cleavage.R03AI151358 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WILSON, ANGUS C · 2020 to 2021
$170k
NIAID NIH HHS R01 AI073898NIAID NIH HHS R01 AI152543NIAID NIH HHS R03 AI151358NIAID NIH HHS R21 AI130618NIAID NIH HHS R21 AI147163NIAID NIH HHS R21 AI151340NIGMS NIH HHS T32 GM008136NINDS NIH HHS R01 NS105630
6 · The paper itself

Abstract

Understanding the molecular mechanisms of herpes simplex virus 1 (HSV-1) latent infection and reactivation in neurons requires the use of

Indexed as

Herpes SimplexHerpesvirus 1, HumanLatent InfectionMAP Kinase Kinase KinasesVirus ActivationVirus LatencyAcyclovirAntiviral AgentsDNA ReplicationDNA, ViralHistone DemethylasesHumansVirus ReplicationAcyclovirAntiviral AgentsDNA, ViralHistone DemethylasesMAP Kinase Kinase Kinasesmitogen-activated protein kinase kinase kinase 12dual leucine zipper kinaseherpes simplex virushuman herpesvirusesin vitro model systemslatent infectionreactivation

Identifiers

PMID35608347
PMCPMC9215246
OpenAlexW4281390898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.