ArticlemBio2022
The Ubiquitous Human Skin Commensal Staphylococcus hominis Protects against Opportunistic Pathogens.
Open access · goldAbstract read
In one paragraph
Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 103 citations in OpenAlex.
- CERS1 is a biomarker of Staphylococcus aureus abundance and atopic dermatitis severity.The Journal of allergy and clinical immunology · 2025Trial
- Rapid reduction in Staphylococcus aureus in atopic dermatitis subjects following dupilumab treatment.The Journal of allergy and clinical immunology · 2023Trial
- Shotgun Metagenomics Reveals Skin Microbiome Composition and Function in Infant Atopic Disease.Allergy · 2026Article
- Targeting Quorum Sensing to Combat Foodborne Pathogens: A Dual Strategy Against Spoilage and Pathogenesis.Foods (Basel, Switzerland) · 2026Review
- Mass spectrometry-based metabolomics approaches to interrogate host-microbiome interactions in mammalian systems.Natural product reports · 2026Review
- Cutibacterium acnes inhibits Staphylococcus lugdunensis biofilm formation through inhibition of autolysis and purine biosynthesis.NPJ biofilms and microbiomes · 2026Article
- SkinApplied and environmental microbiology · 2026Article
- Preliminary Quality and Safety Evaluation of Lycopene-Based Dietary Supplements: Analysis of Active Compound Content, Microbiological Purity, and Chemical Contaminants.Foods (Basel, Switzerland) · 2026Article
- Assessment of Protective Role of Different Probiotic Strains against Bacterial and Endotoxin-Induced Sepsis in a Mouse Model.Probiotics and antimicrobial proteins · 2026Article
- Skin androgens regulate Staphylococcus aureus pathogenicity via quorum sensing.Nature microbiology · 2026Article
- Skin Lipid-Microbe Interplay Links Staphylococcus hominis to Barrier Control in Adult Atopic Dermatitis.Allergy · 2026Article
- Cutibacterium acnes inhibits Staphylococcus lugdunensis biofilm formation through inhibition of autolysis and purine biosynthesis.Research square · 2026Article
- Comparative Profile of Microbiome in Normal Skin and Acne Vulgaris Skin Patients.Clinical, cosmetic and investigational dermatology · 2026Article
- Dynamic remodeling of skin microbiota during healthy homeostatic and wound repair conditions.Frontiers in microbiology · 2026Review
- An antimicrobial daptide from human skin commensal Staphylococcus hominis protects against skin pathogens.Nature communications · 2025Article
- Potentially Zoonotic Bacteria in Exotic Freshwater Turtles from the Canary Islands (Spain).Biology · 2025Article
- The human skin microbiome: from metagenomes to therapeutics.Nature reviews. Microbiology · 2025Review
- Postbiotics as microbial-derived therapeutics for wound healing disorders: from molecular mechanisms to future application.Cell communication and signaling : CCS · 2025Review
- Wounds and the Microbiota: The Healing Interplay Between Host and Microbial Communities.International journal of molecular sciences · 2025Review
- Differential Modulation of Skin Barrier Proteins and Lipid Synthesis byAnnals of dermatology · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Morgan M SevernDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Michael R WilliamsDepartment of Dermatology, University of California, San Diegogrid.266100.3, La Jolla, California, USA.
Ali ShahbandiDepartment of Chemistry and Biochemistry, University of North Carolina at Greensborogrid.266860.c, Greensboro, North Carolina, USA.
Zoie L BunchDepartment of Chemistry and Biochemistry, University of North Carolina at Greensborogrid.266860.c, Greensboro, North Carolina, USA.
Laurie M LyonDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Amber NguyenDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Livia S ZaramelaDepartment of Pediatrics, University of California, San Diegogrid.266100.3, La Jolla, California, USA.
Daniel A ToddDepartment of Chemistry and Biochemistry, University of North Carolina at Greensborogrid.266860.c, Greensboro, North Carolina, USA.
Karsten ZenglerDepartment of Pediatrics, University of California, San Diegogrid.266100.3, La Jolla, California, USA.
Nadja B CechDepartment of Chemistry and Biochemistry, University of North Carolina at Greensborogrid.266860.c, Greensboro, North Carolina, USA.
Richard L GalloDepartment of Dermatology, University of California, San Diegogrid.266100.3, La Jolla, California, USA.
Alexander R HorswillDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-5568-0096
University of California San Diego · USUniversity of North Carolina at Greensboro · USUniversity of Colorado Denver · USVA Eastern Colorado Health Care System · US
Funding
UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4MCathelicidin in Skin ImmunityR37AI052453 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard L Gallo, Victor Nizet · 2019 to 2026
$4.6MMicrobiome Function in Atopic DermatitisU01AI152038 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard L Gallo · 2020 to 2026
$3.3MQuorum sensing, diversity and skin inflammationR01AI153185 · NIAID · UNIVERSITY OF COLORADO DENVER · PI GALLO, RICHARD L, HORSWILL, ALEXANDER R · 2020 to 2024
$3.2MMolecular Pathogenesis of Infectious DiseasesT32AI052066 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAN DYK, LINDA F. · 2002 to 2022
$2.3MConflict and Cooperation between AMP Species on the skinR01AR076082 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L, NAKATSUJI, TERUAKI · 2019 to 2023
$2.3MPredoctoral Training: Innovative Technologies for Natural Products and Integrative Medicine ResearchT32AT008938 · NCCIH · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI Nadja B Cech, Jonathan Rodi Chekan · 2016 to 2026
$1.6MMechanisms of skin commensal colonization resistance against opportunistic StaphylococciF31AI157052 · NIAID · UNIVERSITY OF COLORADO DENVER · PI BROWN, MORGAN · 2021 to 2021
$27kQuorum Sensing Dependent Interactions with Biofilms and Innate Immunity DefensesI01BX002711 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI ALEXANDER R HORSWILL · 2015 to 2026
–BLRD VA I01 BX002711NCCIH NIH HHS T32 AT008938NIAID NIH HHS F31 AI157052NIAID NIH HHS R01 AI153185NIAID NIH HHS R37 AI052453NIAID NIH HHS T32 AI052066NIAID NIH HHS U01 AI152038NIAMS NIH HHS R01 AR076082NIGMS NIH HHS K12 GM068524
Abstract
Staphylococcus hominis is frequently isolated from human skin, and we hypothesize that it may protect the cutaneous barrier from opportunistic pathogens. We determined that S. hominis makes six unique autoinducing peptide (AIP) signals that inhibit the major virulence factor accessory gene regulator (
Indexed as
Staphylococcal InfectionsStaphylococcus aureusAnimalsBacterial ProteinsHumansMicePeptidesStaphylococcusStaphylococcus epidermidisStaphylococcus hominisVirulence FactorsBacterial ProteinsPeptidesVirulence Factorscoagulase-negative staphylococciquorum sensingskin microbiotaStaphylococcus aureus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.