Evidence map›Paper›PMID 35608101›Full record

ArticlePhysiological reports2022

Heart rate variability as a function of menopausal status, menstrual cycle phase, and estradiol level.

Sharanya Ramesh, Matthew T James, Jayna M Holroyd-Leduc, Stephen B Wilton, Darlene Y Sola, Sofia B Ahmed

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sharanya RameshTemerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Matthew T JamesTemerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Jayna M Holroyd-LeducTemerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Stephen B WiltonTemerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Darlene Y SolaTemerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Sofia B AhmedTemerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-3000-2229
University of Calgary · CAUniversity of Toronto · CA

Funding

CIHR
6 · The paper itself

Abstract

Low estradiol status is associated with increased cardiovascular risk. We sought to determine the association between heart rate variability (HRV), a marker of cardiovascular risk, at baseline and in response to stressor as a function of menopausal status, menstrual cycle phase and estradiol level. Forty-one healthy women (13 postmenopausal, 28 premenopausal) were studied. Eleven premenopausal women were additionally studied in the high and low estradiol phases of the menstrual cycle. HRV was calculated by spectral power analysis (low Frequency (LF), high frequency (HF) and LF:HF) at baseline and in response to graded Angiotensin II (AngII) infusion. The primary outcomes were differences in HRV at baseline and in response to AngII. Compared to premenopausal women in the low estradiol phase, postmenopausal women demonstrated lower baseline LF (p = 0.01) and HF (p < 0.001) measures, which were not significant after adjustment for age and BMI. In response to AngII, a decrease in cardioprotective HRV (ΔHF = -0.43 ± 0.46 ln ms

Indexed as

Autonomic Nervous SystemMenstrual CycleAngiotensin IIEstradiolFemaleHeart RateHumansMenopauseAngiotensin IIEstradiolEstrogenfemaleheart rate variabilityMenopausemenstrual cyclewomen

Identifiers

PMID35608101
PMCPMC9127980
OpenAlexW4281385150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.