Evidence map›Paper›PMID 35607980›Full record

ArticleThe Journal of pathology2022

Glomerular basement membrane deposition of collagen α1(III) in Alport glomeruli by mesangial filopodia injures podocytes via aberrant signaling through DDR1 and integrin α2β1.

Jacob Madison, Kevin Wilhelm, Daniel T Meehan, Duane Delimont, Gina Samuelson, Dominic Cosgrove

Open access · hybridAbstract read
In one paragraph

Article in The Journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. New therapeutic hope for rare podocytopathies.Pediatric nephrology (Berlin, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Genotype-Based Molecular Mechanisms in Alport Syndrome.Journal of the American Society of Nephrology : JASN · 2025
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jacob Madison *Boys Town National Research Hospital, Omaha, NE, USA.
Kevin Wilhelm *Boys Town National Research Hospital, Omaha, NE, USA.
Daniel T MeehanBoys Town National Research Hospital, Omaha, NE, USA.
Duane DelimontBoys Town National Research Hospital, Omaha, NE, USA.
Gina SamuelsonBoys Town National Research Hospital, Omaha, NE, USA.
Dominic CosgroveBoys Town National Research Hospital, Omaha, NE, USA.ORCID 0000-0002-5512-7696
Boys Town National Research Hospital · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Heather Colleen Jensen-Smith · 2012 to 2026
$59.2M
ZINC FINGER-INSPIRED FLUORESCENT CHEMOSENSORSP20RR016469 · NCRR · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI TURPEN, JAMES B · 2001 to 2011
$36.2M
Understanding the progression of hearing loss in an endolymphatic hydrops modelP20GM139762 · NIGMS · CREIGHTON UNIVERSITY · PI Hui Hong · 2021 to 2026
$16.1M
Structural Analyses CoreP01AG051443 · NIA · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2016 to 2025
$15.5M
A TEST OF CHILDREN'S ENGLISH/SPANISH SPEECH PERCEPTION IN NOISE OR SPEECH MASKERSR01DC015056 · NIDCD · FATHER FLANAGAN'S BOYS' HOME · PI BUSS, EMILY, LEIBOLD, LORI J. · 2016 to 2020
$3.0M
RESCUE OF ALPORT SYNDROME OTOPATHOLOGYR01DC015385 · NIDCD · FATHER FLANAGAN'S BOYS' HOME · PI COSGROVE, DOMINIC E., GRATTON, MICHAEL ANNE NMI · 2016 to 2020
$2.4M
Calcium-dependent functions in Hair Cells and Spiral Ganglion NeuronsR01DC015135 · NIDCD · UNIVERSITY OF NEVADA RENO · PI GRATTON, MICHAEL ANNE NMI, YAMOAH, EBENEZER N · 2016 to 2020
$2.1M
Regulation of hair cell functionsR01DC015252 · NIDCD · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2017 to 2021
$2.1M
FUNCTIONAL PROPERTIES OF CA PUMPS IN HAIR CELLR01DC004215 · NIDCD · UNIVERSITY OF CINCINNATI · PI YAMOAH, EBENEZER N. · 1999 to 2003
$1.0M
NCRR NIH HHS P20 RR016469NCRR NIH HHS RR016469NIA NIH HHS P01 AG051443NIDCD NIH HHS R01 DC004215NIDCD NIH HHS R01 DC015056NIDCD NIH HHS R01 DC015135NIDCD NIH HHS R01 DC015252NIDCD NIH HHS R01 DC015385NIGMS NIH HHS P20 GM103427NIGMS NIH HHS P20 GM139762
6 · The paper itself

Abstract

In Alport mice, activation of the endothelin A receptor (ET

Indexed as

Nephritis, HereditaryPodocytesAnimalsBasement MembraneCollagen Type IIICollagen Type IVDiscoidin Domain Receptor 1Glomerular Basement MembraneHumansIntegrin alpha2beta1MiceMice, KnockoutPseudopodiaRNACollagen Type IIICollagen Type IVDDR1 protein, humanDiscoidin Domain Receptor 1Integrin alpha2beta1RNAAlport syndromecollagen α1(III)discoidin domain receptor 1integrin α2β1podocyte injury

Identifiers

PMID35607980
PMCPMC9378723
OpenAlexW4282930606

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.