Evidence map›Paper›PMID 35607815›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022

Higher In Vivo Fecal Concentrations of Clostridioides difficile Toxins A and B in Patients With North American Pulsed-Field Gel Electrophoresis Type 1/Ribotype 027 Strain Infection.

Carolyn D Alonso, Nira R Pollock, Kevin W Garey, Anne J Gonzales-Luna, David N Williams, Kaitlyn Daugherty, Christine Cuddemi, Javier Villafuerte-Gálvez, Nicole C White, Xinhua Chen and 8 more

Open access · greenAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Stool Interleukin-1β Differentiates Clostridioides difficile Infection (CDI) From Asymptomatic Carriage and Non-CDI Diarrhea.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Carolyn D AlonsoDivision of Infectious Disease, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID 0000-0002-3140-1128
Nira R PollockDivision of Infectious Disease, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Kevin W GareyDepartment of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.
Anne J Gonzales-LunaDepartment of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.
David N WilliamsInstitutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Massachusetts, USA.
Kaitlyn DaughertyDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID 0000-0002-3718-5585
Christine CuddemiDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Javier Villafuerte-GálvezDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID 0000-0002-3379-5271
Nicole C WhiteDivision of Infectious Disease, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Xinhua ChenDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Hua XuDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Rebecca SpragueDivision of Infectious Disease, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Caitlin BarrettDivision of Infectious Disease, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Mark MillerbioMérieux, Marcy L'Etoile, France.
Agnès FoussadierbioMérieux, Marcy L'Etoile, France.
Aude LantzbioMérieux, Marcy L'Etoile, France.
Alice BanzbioMérieux, Marcy L'Etoile, France.
Ciarán P KellyHarvard Medical School, Boston, Massachusetts, USA.
Beth Israel Deaconess Medical Center · USbioMérieux (France) · FRBoston Children's Hospital · USUniversity of Houston · US

Funding

Ultrasensitive C.difficile toxin measurement for diagnosis and outcome predictionR01AI116596 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI POLLOCK, NIRA · 2016 to 2020
$4.1M
NIAID NIH HHS R01 AI116596
6 · The paper itself

Abstract

Ultrasensitive, quantitative Clostridioides difficile stool toxin measurement demonstrated significantly higher concentrations of toxins A and B in patients infected with the North American pulsed-field gel electrophoresis type 1/ribotype 027 (NAP-1/027) strain compared with other strains, providing in vivo confirmation of the in vitro association between NAP-1/027 and elevated toxin production.

Indexed as

Bacterial ToxinsClostridioides difficileClostridium InfectionsAntibodies, BacterialBacterial ProteinsElectrophoresis, Gel, Pulsed-FieldEnterotoxinsFecesHumansNorth AmericaRibotypingAntibodies, BacterialBacterial ProteinsBacterial ToxinsEnterotoxinsclinical outcomesClostridioides difficileNAP-1/027 straintoxin concentration

Identifiers

PMID35607815
PMCPMC10200326
OpenAlexW4282917625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.