Evidence map›Paper›PMID 35607710›Full record

Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022

Cumulative Mycobacterium tuberculosis Infection Incidence (Measured Primarily by Tuberculin Skin Test) Among Infants With Human Immunodeficiency Virus Exposure: Observational Follow-up of an Isoniazid Prophylaxis Trial.

Sylvia M LaCourse, Jaclyn N Escudero, Jerphason Mecha, A J Warr, Barbra A Richardson, Naziat Carimo, Lisa M Cranmer, Elizabeth Maleche-Obimbo, Daniel Matemo, John Kinuthia and 2 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02613169 (Preventing Mycobacterium Tuberculosis Infection in HIV-Exposed Infants), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02613169 phase2completednot on this map

Preventing Mycobacterium Tuberculosis Infection in HIV-Exposed Infants

TypeinterventionalSponsorUniversity of WashingtonRan2016 to 2020Enrolled300ConditionsTuberculosisArmsIsoniazid
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Sylvia M LaCourseDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-9809-5997
Jaclyn N EscuderoDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Jerphason MechaMedical Research Department, Kenyatta National Hospital, Nairobi, Kenya.
A J WarrDepartment of Pediatrics and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Barbra A RichardsonDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Naziat CarimoDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Lisa M CranmerDivision of Infectious Diseases, Department of Pediatrics, Emory University, Atlanta, Georgia, USA.
Elizabeth Maleche-ObimboDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Daniel MatemoMedical Research Department, Kenyatta National Hospital, Nairobi, Kenya.
John KinuthiaDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Thomas R HawnDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
Grace John-StewartDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
University of Washington · USKenyatta National Hospital · KEBaylor College of Medicine · USEmory University · USUniversity of Nairobi · KE

Funding

Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
Seattle Tuberculosis Research Advancement CenterP30AI168034 · NIAID · UNIVERSITY OF WASHINGTON · PI CHETAN SESHADRI · 2022 to 2026
$6.3M
Northern/Pacific Universities Global Health Research Training ConsortiumR25TW009345 · FIC · UNIVERSITY OF WASHINGTON · PI KOLARS, JOSEPH C., NERURKAR, VIVEK RAMCHANDRA · 2012 to 2016
$5.9M
Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Jeffrey M Collins · 2022 to 2026
$5.8M
The role of antibodies in infant TB preventionK23AI143479 · NIAID · EMORY UNIVERSITY · PI CRANMER, LISA M · 2019 to 2023
$950k
Impact of maternal HIV on Mycobacterium tuberculosis infection among peripartum women and their infantsK23AI120793 · NIAID · UNIVERSITY OF WASHINGTON · PI LACOURSE, SYLVIA · 2016 to 2020
$910k
Pulmonary Innate Immunity & Resistance to Mycobacterium Tuberculosis InfectionK24AI137310 · NIAID · UNIVERSITY OF WASHINGTON · PI HAWN, THOMAS R · 2018 to 2022
$892k
FIC NIH HHS R25 TW009345NCATS NIH HHS UL1 TR000423NIAID NIH HHS K23 AI120793NIAID NIH HHS K23 AI143479NIAID NIH HHS K24 AI137310NIAID NIH HHS P30 AI168034NIAID NIH HHS P30 AI168386
6 · The paper itself

Abstract

Cumulative 24-month Mycobacterium tuberculosis infection incidence (measured primarily by tuberculin skin test [TST]) was high among human immunodeficiency virus exposed but uninfected infants (8.7 [95% confidence interval, 6.3-11.9] per 100 person-years). Trend for decreased TST positivity among infants at trial end (12 months postenrollment) randomized to isoniazid at 6 weeks of age was not sustained through observational follow-up to 24 months of age. CLINICAL TRIALS REGISTRATION: NCT02613169.

Indexed as

HIV InfectionsMycobacterium tuberculosisTuberculosisAntitubercular AgentsChild, PreschoolFollow-Up StudiesHIVHumansIncidenceInfantIsoniazidTuberculin TestAntitubercular AgentsIsoniazidHIV-exposed infantisoniazidM. tuberculosis infectiontuberculin skin test

Identifiers

PMID35607710
PMCPMC10200296
OpenAlexW4281388828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.