Evidence map›Paper›PMID 35607619›Full record

ArticlePatterns (New York, N.Y.)2022

Deep forecasting of translational impact in medical research.

Amy P K Nelson, Robert J Gray, James K Ruffle, Henry C Watkins, Daniel Herron, Nick Sorros, Danil Mikhailov, M Jorge Cardoso, Sebastien Ourselin, Nick McNally and 3 more

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Reframing research impact.Patterns (New York, N.Y.) · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amy P K NelsonHigh Dimensional Neurology Group, UCL Queen Square Institute of Neurology, University College London, Russell Square House, Bloomsbury, London WC1B 5EH, UK.
Robert J GrayHigh Dimensional Neurology Group, UCL Queen Square Institute of Neurology, University College London, Russell Square House, Bloomsbury, London WC1B 5EH, UK.
James K RuffleHigh Dimensional Neurology Group, UCL Queen Square Institute of Neurology, University College London, Russell Square House, Bloomsbury, London WC1B 5EH, UK.
Henry C WatkinsHigh Dimensional Neurology Group, UCL Queen Square Institute of Neurology, University College London, Russell Square House, Bloomsbury, London WC1B 5EH, UK.
Daniel HerronResearch & Development, NIHR University College London Hospitals Biomedical Research Centre, London WC1E 6BT, UK.
Nick SorrosWellcome Data Labs, Wellcome Trust, London NW1 2BE, UK.
Danil MikhailovWellcome Data Labs, Wellcome Trust, London NW1 2BE, UK.
M Jorge CardosoSchool of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
Sebastien OurselinSchool of Biomedical Engineering & Imaging Sciences, King's College London, London WC2R 2LS, UK.
Nick McNallyResearch & Development, NIHR University College London Hospitals Biomedical Research Centre, London WC1E 6BT, UK.
Bryan WilliamsResearch & Development, NIHR University College London Hospitals Biomedical Research Centre, London WC1E 6BT, UK.
Geraint E ReesHigh Dimensional Neurology Group, UCL Queen Square Institute of Neurology, University College London, Russell Square House, Bloomsbury, London WC1B 5EH, UK.
Parashkev NachevHigh Dimensional Neurology Group, UCL Queen Square Institute of Neurology, University College London, Russell Square House, Bloomsbury, London WC1B 5EH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The value of biomedical research-a $1.7 trillion annual investment-is ultimately determined by its downstream, real-world impact, whose predictability from simple citation metrics remains unquantified. Here we sought to determine the comparative predictability of future real-world translation-as indexed by inclusion in patents, guidelines, or policy documents-from complex models of title/abstract-level content versus citations and metadata alone. We quantify predictive performance out of sample, ahead of time, across major domains, using the entire corpus of biomedical research captured by Microsoft Academic Graph from 1990-2019, encompassing 43.3 million papers. We show that citations are only moderately predictive of translational impact. In contrast, high-dimensional models of titles, abstracts, and metadata exhibit high fidelity (area under the receiver operating curve [AUROC] > 0.9), generalize across time and domain, and transfer to recognizing papers of Nobel laureates. We argue that content-based impact models are superior to conventional, citation-based measures and sustain a stronger evidence-based claim to the objective measurement of translational potential.

Indexed as

deep learningnatural language processingrepresentation learningresearch impacttranslational research

Identifiers

PMID35607619
PMCPMC9122964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.