SynthesisJournal of translational medicine2022
Association between physical activity and infertility: a comprehensive systematic review and meta-analysis.
Synthesis in Journal of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Association between physical activity and knee osteoarthritis: a comprehensive systematic review and meta-analysis.Journal of global health · 2025Pooled it
- Physical activity and constipation: A systematic review of cohort studies.Journal of global health · 2024Pooled it
- Effect of zero-time exercise intervention on endometrial receptivity in women with thin endometrium a single-center randomized sham-controlled trial.Archives of gynecology and obstetrics · 2026Trial
- Reactive Oxygen and Nitrogen Species in Male Reproductive Health: From Molecular Mechanisms to Clinical Consequences.Antioxidants (Basel, Switzerland) · 2026Review
- Association between history of fertility problems and pregnancy and birth complications: A longitudinal population-based cohort study.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Dietary patterns, physical activity, and nutrient intake among infertile women in an Iranian setting: a cross-sectional study.BMC women's health · 2026Article
- The protective effect of pregnancy on risk for suicide attempt in a Swedish national cohort.Scientific reports · 2026Article
- The relationship between physical activity and subjective wellbeing in infertile women: the mediating role of positive feedback and self-efficacy.Frontiers in public health · 2026Article
- Dyadic associations of physical activity intensity with fertility-related quality of life in infertile couples: an APIM analysis.Frontiers in public health · 2026Article
- Male infertility and risk of cardiometabolic conditions: a population-based cohort study.Human reproduction (Oxford, England) · 2026Article
- Impact of oxidative stress on female reproductive parameters: an analysis of systemic and follicular biomarkers.JBRA assisted reproduction · 2025Article
- Women's health and female fertility: current evidence and knowledge gaps in the Asia-Pacific region.The Lancet regional health. Western Pacific · 2025Review
- A long shot? Affective temperaments predict adherence to pharmacotherapy during infertility treatment in a prospective longitudinal study.Dialogues in clinical neuroscience · 2025Article
- Unexplained infertility's determinants, correlation with bacterial vaginosis and anti-sperm antibodies among Congolese women: a case‒control study.BMC women's health · 2025Article
- 24-Hour Movement Behaviour and Health Awareness as Possible Predictors of Infertility-Related Quality of Life.Journal of clinical medicine · 2025Article
- A retrospective study on the association of ambient air pollutants and temperature co-exposure with female infertility risk in Chengdu, China.Scientific reports · 2025Article
- Life's crucial 9 is inversely and linearly associated with female infertility prevalence: a cross-sectional analysis from NHANES 2013-2018.Scientific reports · 2025Article
- The association between glycated hemoglobin, physical activity and infertility: a multiple logistic regression and mediation analysis based on the NHANES database.Frontiers in endocrinology · 2025Article
- Deciphering the association between the Life's Essential 8 and infertility: insights into depression, inflammation, and metabolic mediation.Frontiers in endocrinology · 2025Article
- Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysical activity (PA) may protect against infertility by modulating the hypothalamic-pituitary-gonadal axis, thereby reducing gonadotropin levels, elevating immune function, and inhibiting inflammation and circulating sex hormones. However, whether PA reduces the risk of infertility remains largely unknown. We therefore conducted a systematic review and meta-analysis to determine the preventive effects of PA on infertility.
methodsWe searched PubMed, Cochrane Library, EMBASE, and CINAHL databases to retrieve published epidemiologic studies on the relationship between PA and infertility. Following the PRISMA guidelines, we selected English literature publishedprior to 11 April 2022, and assessed study quality using the Newcastle-Ottawa Scale. Our protocol, including the full methods employed for this review, is available on PROSPERO (ID = CRD42020143344).
resultsSix cohort studies and four case-control studies based on 708,965 subjects and 12,580 cases were eventually screened and retained. High levels of PA were shown to reduced risk of infertility relative to low levels (cumulative relative risk [RR] = 0.59, with a 95% confidence interval CI 0.49-0.71), and we reported results for cohort studies (RR = 0.63, 95% CI 0.50-0.79) and case-control studies (RR = 0.49, 95% CI 0.35-0.67). Our findings were comparable for men (RR = 0.65, 95% CI 0.41-1.04) and women (RR = 0.56, 95% CI 0.47-0.66). The meta-analysis of six risk estimates from five studies of low, moderate, and high PA levels showed that moderate PA may also reduce the risk of infertility compared with low PA (RR = 0.54, 95% CI 0.38-0.77). However, high PA also appeared to slightly augment the risk of infertility compared with moderate PA (RR = 1.31, 95% CI 1.08-1.59).
conclusionsThis present systematic review comprehensively reflected an inverse relationship between different levels of PA and infertility, and our meta-analysis showed that a moderate-to-high PA level significantly reduced the overall risk of infertility, and that this level of PA activity was a common protective factor. In addition, limited evidence suggested that compliance with international PA guidelines would greatly lower the risk of infertility (RR = 0.58, 95% CI 0.45-0.74; I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.