ArticleAlzheimer's research & therapy2022
Dynamic functional connectivity patterns associated with dementia risk.
Article in Alzheimer's research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Dissociable, species-specific impact of Aβ on static and dynamic functional connectomes.bioRxiv : the preprint server for biology · 2026Article
- Activity Patterns in Relation to Dynamic Functional Network States: A Longitudinal Feasibility Study of Brain-Behavior Associations in Young Adults.Brain sciences · 2026Article
- A Study on dynamic functional connectivity and efficacy prediction of SAINT for rapid antidepressant effects and relief of suicidal ideation.Translational psychiatry · 2025Article
- Abnormal intrinsic brain functional network dynamics in delayed encephalopathy after carbon monoxide poisoning.Scientific reports · 2025Article
- Abnormal functional network connectivity mediates the relationship between depressive symptoms and cognitive decline in late-onset depression.Psychological medicine · 2025Article
- Neuroimage Analysis Methods and Artificial Intelligence Techniques for Reliable Biomarkers and Accurate Diagnosis of Schizophrenia: Achievements Made by Chinese Scholars Around the Past Decade.Schizophrenia bulletin · 2025Review
- Article
- Effects of an 18-month meditation training on dynamic functional connectivity states in older adults: Secondary analyses from the Age-Well randomized controlled trial.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Altered dynamic functional network connectivity patterns in Alzheimer's disease: insights into neural dysfunction.Frontiers in aging neuroscience · 2025Article
- Unraveling the brain dynamics of Depersonalization-Derealization Disorder: a dynamic functional network connectivity analysis.BMC psychiatry · 2024Article
- Alterations in Dynamic Functional Connectivity in Patients with Cerebral Small Vessel Disease.Translational stroke research · 2024Article
- Dynamic functional connectivity MEG features of Alzheimer's disease.NeuroImage · 2023Article
- Biological Risk Factors Influencing Vascular Cognitive Impairments: A Review of the Evidence.Brain sciences · 2023Review
- Young and old adult brains experience opposite effects of acute sleep restriction on the functional connectivity network.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
17 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study assesses the relationships between dynamic functional network connectivity (DFNC) and dementia risk.
methodsDFNC of the default mode (DMN), salience (SN), and executive control networks was assessed in 127 cognitively unimpaired older adults. Stepwise regressions were performed with dementia risk and protective factors and biomarkers as predictors of DFNC.
resultsAssociations were found between times spent in (i) a "weakly connected" state and lower self-reported engagement in early- and mid-life cognitive activity and higher LDL cholesterol; (ii) a "SN-negatively connected" state and higher blood pressure, higher depression score, and lower body mass index (BMI); (iii) a "strongly connected" state and higher self-reported engagement in early-life cognitive activity, Preclinical Alzheimer's cognitive composite-5 score, and BMI; and (iv) a "DMN-negatively connected" state and higher self-reported engagement in early- and mid-life stimulating activities and lower LDL cholesterol and blood pressure. The lower number of state transitions was associated with lower brain perfusion.
conclusionDFNC states are differentially associated with dementia risk and could underlie reserve.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.