ArticleBMC genomics2022
Identification of sex determination locus in sea cucumber Apostichopus japonicus using genome-wide association study.
Article in BMC genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 43 citations in OpenAlex.
- Nano Selenium Supplementation Improves Antioxidation, Immunity and Selenoprotein Genes Expressions in Juvenile Sea Cucumber (Apostichopus japonicus).Biological trace element research · 2026Article
- Sex Determination in Sponges.Molecular reproduction and development · 2026Review
- Article
- Application of restriction endonuclease enzymes for sex determination in selected mammalian species.Molecular biology reports · 2025Article
- Identification of Key Biomarkers of Growth-Related Traits in the Bay Scallop Argopecten irradians irradians via Multi-omics Analysis Strategies.Marine biotechnology (New York, N.Y.) · 2025Article
- Identification of a candidate sex determination region and sex-specific molecular markers based on whole-genome re‑sequencing in the sea star Asterias amurensis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Article
- Identification and expression analysis of Sox family genes in echinoderms.BMC genomics · 2024Article
- Chromosomal-level genome assembly and annotation of the tropical sea cucumber Holothuria scabra.Scientific data · 2024Article
- Sea cucumbers: an emerging system in evo-devo.EvoDevo · 2024Review
- A high-quality chromosomal genome assembly of the sea cucumber Chiridota heheva and its hydrothermal adaptation.GigaScience · 2024Article
- Exploring the cobia (Rachycentron canadum) genome: unveiling putative male heterogametic regions and identification of sex-specific markers.GigaScience · 2024Article
- Article
- Chromosome-level genome assembly of the sea cucumber Apostichopus japonicus.Scientific data · 2023Article
- Genome-wide identification and comparative analysis of Dmrt genes in echinoderms.Scientific reports · 2023Article
- Trioecy is maintained as a time-stable mating system in the pink sea urchin Toxopneustes roseus from the Mexican Pacific.Scientific reports · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSex determination mechanisms are complicated and diverse across taxonomic categories. Sea cucumber Apostichopus japonicus is a benthic echinoderm, which is the closest group of invertebrates to chordate, and important economic and ecologically aquaculture species in China. A. japonicus is dioecious, and no phenotypic differences between males and females can be detected before sexual maturation. Identification of sex determination locus will broaden knowledge about sex-determination mechanism in echinoderms, which allows for the identification of sex-linked markers and increases the efficiency of sea cucumber breeding industry.
resultsHere, we integrated assembly of a novel chromosome-level genome and resequencing of female and male populations to investigate the sex determination mechanisms of A. japonicus. We built a chromosome-level genome assembly AJH1.0 using Hi-C technology. The assembly AJH1.0 consists of 23 chromosomes ranging from 22.4 to 60.4 Mb. To identify the sex-determination locus of A. japonicus, we conducted genome-wide association study (GWAS) and analyses of distribution characteristics of sex-specific SNPs and fixation index F
conclusionsIn the present study, we integrated genome-wide association study and analyses of sex-specific variations to investigate sex determination mechanisms. This will bring novel insights into gene regulation during primitive gonadogenesis and differentiation and identification of master sex determination gene in sea cucumber. In the sea cucumber industry, investigation of molecular mechanisms of sex determination will be helpful for artificial fertilization and precise breeding.
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