Evidence map›Paper›PMID 35606684›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2022

Biocoating-A Critical Step Governing the Oral Delivery of Polymeric Nanoparticles.

Aharon Azagury, Cameron Baptista, Kosta Milovanovic, Hyeseon Shin, Peter Morello, James Perez-Rogers, Victoria Goldenshtein, Travis Nguyen, Arianna Markel, Soham Rege and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. A basedMaterials today. Bio · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Advances in nanomaterial-based targeted drug delivery systems.Frontiers in bioengineering and biotechnology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Aharon AzaguryNoninvasive Biomimetic Drug Delivery Systems Lab, The Department of Chemical Engineering, Ariel Center for Applied Cancer Research (ACACR), Ariel University, Ramat HaGolan St 65, Ari'el, 40700000, Israel.
Cameron BaptistaDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.
Kosta MilovanovicDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.
Hyeseon ShinDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.
Peter MorelloDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.
James Perez-RogersDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.
Victoria GoldenshteinDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.
Travis NguyenDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.
Arianna MarkelDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.
Soham RegeDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.
Stephanie HojsakDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.
Alexander PerlDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.
Carder JonesDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.
Megan FifeDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.
Stacia FurtadoDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.
Edith MathiowitzDepartment of Pathology and Laboratory Medicine, Center of Biomedical Engineering, Brown University, 171 Meeting Street, Box G-B3, Providence, RI, 02912, USA.ORCID 0000-0003-3054-7130
Brown University · USAriel University · IL

Funding

SEM for serial block-face imagingS10OD023461 · OD · BROWN UNIVERSITY · PI CRETON, ROBBERT J · 2017 to 2017
$791k
BIOADHESIVE MICROSPHERESR01EB000248 · NIBIB · BROWN UNIVERSITY · PI MATHIOWITZ, EDITH · 2002 to 2002
$308k
NIBIB NIH HHS R01 EB000248NIH HHS S10 OD023461NIH HHS S10OD023461
6 · The paper itself

Abstract

Decades of research into the topic of oral nanoparticle (NP) delivery has still not provided a clear consensus regarding which properties produce an effective oral drug delivery system. The surface properties-charge and bioadhesiveness-as well as in vitro and in vivo correlation seem to generate the greatest number of disagreements within the field. Herein, a mechanism underlying the in vivo behavior of NPs is proposed, which bridges the gaps between these disagreements. The mechanism relies on the idea of biocoating-the coating of NPs with mucus-which alters their surface properties, and ultimately their systemic uptake. Utilizing this mechanism, several coated NPs are tested in vitro, ex vivo, and in vivo, and biocoating is found to affect NPs size, zeta-potential, mucosal diffusion coefficient, the extent of aggregation, and in vivo/in vitro/ex vivo correlation. Based on these results, low molecular weight polylactic acid exhibits a 21-fold increase in mucosal diffusion coefficient after precoating as compared to uncoated particles, as well as 20% less aggregation, and about 30% uptake to the blood in vivo. These discoveries suggest that biocoating reduces negative NP charge which results in an enhanced mucosal diffusion rate, increased gastrointestinal retention time, and high systemic uptake.

Indexed as

Drug CarriersNanoparticlesAdministration, OralDrug Delivery SystemsMucusPolymersDrug CarriersPolymersbioadhesiondrug deliverygastrointestinal (GI) transportmucus diffusionnanoparticles

Identifiers

PMID35606684
PMCPMC9250634
OpenAlexW4281390364

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.