Evidence map›Paper›PMID 35606396›Full record

ArticleScientific reports2022

Activity of alkaloids from Aspidosperma nitidum against Leishmania (Leishmania) amazonensis.

Andreza do Socorro Silva da Veiga, Fernando Tobias Silveira, Edilene Oliveira da Silva, José Antônio Picanço Diniz Júnior, Sanderson Corrêa Araújo, Marliane Batista Campos, Andrey Moacir do Rosário Marinho, Geraldo Célio Brandão, Valdicley Vieira Vale, Sandro Percário and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Frontiers in chemistry · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Andreza do Socorro Silva da VeigaPostgraduate Program in Pharmaceutical Innovation, Institute of Health Sciences, Federal University of Pará, Belém, PA, Brazil.
Fernando Tobias SilveiraInstitute Evandro Chagas, Ananindeua, PA, Brazil.
Edilene Oliveira da SilvaPostgraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
José Antônio Picanço Diniz JúniorInstitute Evandro Chagas, Ananindeua, PA, Brazil.
Sanderson Corrêa AraújoInstitute Evandro Chagas, Ananindeua, PA, Brazil.
Marliane Batista CamposInstitute Evandro Chagas, Ananindeua, PA, Brazil.
Andrey Moacir do Rosário MarinhoPostgraduate Program in Biodiversity and Biotechnology of the BIONORTE Network, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Geraldo Célio BrandãoSchool of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG, Brazil.
Valdicley Vieira ValePostgraduate Program in Pharmaceutical Innovation, Institute of Health Sciences, Federal University of Pará, Belém, PA, Brazil.
Sandro PercárioPostgraduate Program in Biodiversity and Biotechnology of the BIONORTE Network, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Maria Fâni DolabelaPostgraduate Program in Pharmaceutical Innovation, Institute of Health Sciences, Federal University of Pará, Belém, PA, Brazil. fani@ufpa.br.
Universidade Federal do Pará · BRInstituto Evandro Chagas · BRUniversidade Federal de Ouro Preto · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the morphological changes caused by fractions and subfractions, obtained from barks of Aspidosperna nitidum, against L. (L.) amazonensis promastigotes. The ethanolic extract (EE) obtained through the maceration of trunk barks was subjected to an acid-base partition, resulting the neutral (FN) and the alkaloid (FA) fractions, and fractionation under reflux, yielded hexane (FrHEX), dichloromethane (FrDCL), ethyl acetate (FrACoET), and methanol (FrMEOH) fractions. The FA was fractionated and three subfractions (SF5-6, SF8, and SF9) were obtained and analyzed by HPLC-DAD and

Indexed as

AlkaloidsAntiprotozoal AgentsAspidospermaLeishmaniaIndole AlkaloidsPlant ExtractsAlkaloidsAntiprotozoal AgentsIndole AlkaloidsPlant Extracts

Identifiers

PMID35606396
PMCPMC9126982
OpenAlexW4281397326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.