Evidence map›Paper›PMID 35606358›Full record

ArticleNature communications2022

Synthetic lethality between TP53 and ENDOD1.

Zizhi Tang, Ming Zeng, Xiaojun Wang, Chang Guo, Peng Yue, Xiaohu Zhang, Huiqiang Lou, Jun Chen, Dezhi Mu, Daochun Kong and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Promising predictive molecular biomarkers for cervical cancer (Review).International journal of molecular medicine · 2024
    Review
  5. Unravelling turbot (Frontiers in immunology · 2024
    Article
  6. Article
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Zizhi Tang *Department of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, 610041, Chengdu, China.ORCID 0000-0002-4768-6148
Ming Zeng *Department of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, 610041, Chengdu, China.ORCID 0000-0001-6387-546X
Xiaojun Wang *Department of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, 610041, Chengdu, China.ORCID 0000-0002-8794-3268
Chang GuoDepartment of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, 610041, Chengdu, China.
Peng YueDepartment of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, 610041, Chengdu, China.
Xiaohu ZhangDepartment of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, 610041, Chengdu, China.
Huiqiang LouSchool of Life Sciences, China Agricultural University, 100193, Beijing, China.
Jun ChenCollege of Life Sciences, Zhejiang University, 310058, Hangzhou, China.ORCID 0000-0002-4459-8804
Dezhi MuDepartment of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, 610041, Chengdu, China.
Daochun KongSchool of Life Sciences, Peking University, 100871, Beijing, China.
Antony M CarrGenome Damage and Stability Centre, School of Life Science, University of Sussex, Falmer, BN1 9RQ, UK. a.m.carr@sussex.ac.uk.ORCID 0000-0002-2028-2389
Cong LiuDepartment of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, 610041, Chengdu, China. congliu@scu.edu.cn.
Sichuan University · CNUniversity of Sussex · GBChina Agricultural University · CNPeking University · CNZhejiang University · CN

Funding

Wellcome TrustWellcome Trust 110047/Z/15/Z
6 · The paper itself

Abstract

The atypical nuclease ENDOD1 functions with cGAS-STING in innate immunity. Here we identify a previously uncharacterized ENDOD1 function in DNA repair. ENDOD1 is enriched in the nucleus following H

Indexed as

NeoplasmsSynthetic Lethal MutationsAnimalsDNA RepairHumansHydrogen PeroxideMiceTumor Suppressor Protein p53Hydrogen PeroxideTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID35606358
PMCPMC9126970
OpenAlexW4281289836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.