Evidence map›Paper›PMID 35606300›Full record

ArticleObesity research & clinical practice

The missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans.

Haoyi Fu, Nicola L Hawley, Jenna C Carlson, Emily M Russell, Alysa Pomer, Hong Cheng, Take Naseri, Muagututi'a Sefuiva Reupena, Ranjan Deka, Courtney C Choy and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity research & clinical practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Validity of anthropometric equation-based estimators of fat mass in Samoan adults.American journal of human biology : the official journal of the Human Biology Council · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Haoyi FuDepartment of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Nicola L HawleyInternational Health Institute, Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA; Department of Epidemiology (Chronic Disease), School of Public Health, Yale University, New Haven, CT, USA.
Jenna C CarlsonDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Department of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Emily M RussellDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Alysa PomerDepartment of Anthropology, Yale University, New Haven, CT, USA.
Hong ChengDepartment of Environmental & Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Take NaseriInternational Health Institute, Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA; Ministry of Health, Apia, Samoa.
Muagututi'a Sefuiva ReupenaLutia i Puava ae Mapu i Fagalele, Apia, Samoa.
Ranjan DekaDepartment of Environmental & Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Courtney C ChoyInternational Health Institute, Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA; Department of Epidemiology (Chronic Disease), School of Public Health, Yale University, New Haven, CT, USA.
Stephen T McGarveyInternational Health Institute, Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA; Department of Anthropology, Brown University, Providence, RI, USA.
Ryan L MinsterDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Daniel E WeeksDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Department of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: weeks@pitt.edu.
University of Pittsburgh · USBrown University · USUniversity of Cincinnati Medical Center · USYale University · USNational University of Samoa · WS

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Integrated cellular, mouse and human research on a novel missense variant influencing adiposity in SamoansR01HL093093 · NHLBI · BROWN UNIVERSITY · PI MCGARVEY, STEPHEN T. · 2009 to 2019
$8.2M
Next Generation Association Studies of Adiposity in Samoans Enhanced by a Samoan-Specific Whole Genome Sequence Reference PanelR01HL133040 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ryan Lee Minster · 2017 to 2026
$7.5M
A multilevel and structural equation modeling approach to understand longitudinal growth, obesity, and cardiometabolic risk among Samoan childrenF31HL147414 · NHLBI · BROWN UNIVERSITY · PI CHOY, COURTNEY CHEU LIN · 2019 to 2020
$91k
NHLBI NIH HHS F31 HL147414NHLBI NIH HHS R01 HL093093NHLBI NIH HHS R01 HL133040NIEHS NIH HHS P30 ES006096
6 · The paper itself

Abstract

objectiveA missense variant, rs373863828, in CREBRF is associated with obesity in Polynesians. We investigate whether rs373863828 and other factors are associated with body mass index (BMI) rate-of-change between 2010 and 2017-19 in Samoans.

methodsWe used sex-stratified models to test whether BMI rate-of-change was associated with rs373863828, baseline BMI, age, residence, physical activity, and household asset score in a cohort study of 480 Samoan adults measured in both 2010 (mean age 43.8 years) and 2017-19.

resultsMean BMI increased from 32.1 to 33.5 kg/m

conclusionsIn Samoans, the minor A allele of rs373863828 is associated with an increased rate-of-change in BMI in females. On average, BMI of females with the AA genotype increased 0.30 kg/m

Indexed as

ObesityAdultAgedAllelesBody Mass IndexCohort StudiesFemaleGenotypeHumansMaleBody mass indexCREBRFLongitudinal changesSamoans

Identifiers

PMID35606300
PMCPMC9373717
OpenAlexW4280519978

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.