ArticleJournal of cachexia, sarcopenia and muscle2022
Declines in muscle protein synthesis account for short-term muscle disuse atrophy in humans in the absence of increased muscle protein breakdown.
Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Age-related anabolic resistance and post-absorptive muscle protein synthesis: integrative evidence from a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Leucine supplementation does not attenuate the decline in daily muscle protein synthesis rates or preserve leg muscle mass during leg immobilization in young or older adults: a double-blind randomized trial.The American journal of clinical nutrition · 2026Trial
- The effects of whey, pea, and collagen protein supplementation beyond the recommended dietary allowance on integrated myofibrillar protein synthetic rates in older males: a randomized controlled trial.The American journal of clinical nutrition · 2024Trial
- Short-term disuse does not affect postabsorptive or postprandial muscle protein fractional breakdown rates.Journal of cachexia, sarcopenia and muscle · 2023Trial
- Musculoskeletal decay and bone-muscle crosstalk during physical disuse: Mechanisms and integrated countermeasures.Experimental physiology · 2026Review
- Article
- Muscle atrophy after ACL reconstruction involves molecular mechanisms beyond unloading.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- The effects of bed rest on cardiometabolic health: A systematic review and meta-analysis.Experimental physiology · 2026Article
- The Influence of Acute Beta-Hydroxy Beta-Methylbutyrate (HMB) Ingestion on the Human Skeletal Muscle Transcriptome.Nutrients · 2026Article
- Assessing the Quality of YouTube Videos Related to Perioperative Nutrition for Patients Undergoing Total Joint Arthroplasty.Arthroplasty today · 2025Article
- The effect of bed rest, unilateral limb immobilization and head-down tilt on muscle protein synthesis: A systematic review and meta-analysis.Experimental physiology · 2025Review
- Integrated muscle protein synthesis during disuse and rehabilitation in late-midlife adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Dietary nitrate preserves mitochondrial bioenergetics and mitochondrial protein synthesis rates during short-term immobilization in mice.The Journal of physiology · 2025Article
- Investigating muscle protein synthesis using deuterium oxide: The impact of dietary protein interventions across the lifespan.Experimental physiology · 2025Review
- Daily blood flow restriction does not preserve muscle mass and strength during 2 weeks of bed rest.The Journal of physiology · 2025Article
- Quantifying Leg Muscle Disuse Atrophy During Bed Rest Using DXA, CT, and MRI.European journal of sport science · 2025Article
- Low-Carbohydrate Diet Exacerbates Denervation-Induced Atrophy of Rat Skeletal Muscle Under the Condition of Identical Protein Intake.Journal of cachexia, sarcopenia and muscle · 2025Article
- Nutritional Interventions to Attenuate Quadriceps Muscle Deficits following Anterior Cruciate Ligament Injury and Reconstruction.Sports medicine (Auckland, N.Z.) · 2025Review
- Turning over new ideas in human skeletal muscle proteostasis: What do we know and where to from here?Experimental physiology · 2025Review
- A single bout of prior resistance exercise attenuates muscle atrophy and declines in myofibrillar protein synthesis during bed-rest in older men.The Journal of physiology · 2025Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundWe determined the short-term (i.e. 4 days) impacts of disuse atrophy in relation to muscle protein turnover [acute fasted-fed muscle protein synthesis (MPS)/muscle protein breakdown (MPB) and integrated MPS/estimated MPB].
methodsHealthy men (N = 9, 22 ± 2 years, body mass index 24 ± 3 kg m
resultsImmobilization decreased TLM [pre: 7477 ± 1196 g, post: 7352 ± 1209 g (P < 0.01)], MT [pre: 2.67 ± 0.50 cm, post: 2.55 ± 0.51 cm (P < 0.05)], and strength [pre: 260 ± 43 N m, post: 229 ± 37 N m (P < 0.05)] with no change in control legs. Integrated MPS decreased in immob vs. control legs [control: 1.55 ± 0.21% day
conclusionsHuman skeletal muscle disuse atrophy is driven by declines in MPS, not increases in MPB. Pro-anabolic therapies to mitigate disuse atrophy would likely be more effective than therapies aimed at attenuating protein degradation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.