Evidence map›Paper›PMID 35605186›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2022

Nickel and Copper Catalyzed ipso-Phosphonodifluoromethylation of Arylboronic Acids with BrCF

Alexander Knieb, Vinayak Krishnamurti, Xanath Ispizua-Rodriguez, G K Surya Prakash

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Difluoroalkylation of Anilines via Photoinduced Methods.The Journal of organic chemistry · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander KniebLoker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California, 90089-1661, United States.ORCID http://orcid.org/0000-0002-0143-2986
Vinayak KrishnamurtiLoker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California, 90089-1661, United States.ORCID http://orcid.org/0000-0001-5850-4541
Xanath Ispizua-RodriguezLoker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California, 90089-1661, United States.ORCID http://orcid.org/0000-0003-4940-501X
G K Surya PrakashLoker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California, 90089-1661, United States.ORCID http://orcid.org/0000-0002-6350-8325

Funding

Loker Hydrocarbon Research Institute, University of Southern California
6 · The paper itself

Abstract

A convenient method for the direct ipso-phosphonodifluoromethylation of arylboronic acids via nickel-copper co-catalysis is disclosed. This work, which utilizes inexpensive first row transition metals, represents a facile alternative to the traditional palladium catalyzed approach. The method utilizes inexpensive commodity chemicals and substrates while tolerating a variety of biologically relevant functional groups. Structurally diverse phosphonodifluoromethylarenes are furnished in good yields under short reaction times. Control experiments to probe possible reaction pathways are also included.

Indexed as

CopperNickelBoronic AcidsCatalysisMolecular StructurePalladiumBoronic AcidsCopperNickelPalladiumboronic acidcatalysiscoppercross-couplingfluorinenickelphosphonodifluoromethyl

Identifiers

PMID35605186
PMCPMC9401585

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.