ArticleBrain and behavior2022
The medial prefrontal cortex to the medial amygdala connections may affect the anxiety level in aged rats.
Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 20 citations in OpenAlex.
- Aging effects on emotionality, cognition and brain mononuclear cells in Sprague-Dawley rats of both sexes.npj aging · 2026Article
- Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Low-temperature resin embedding of the whole brain for various precise structures dissection.iScience · 2023Article
- Young adult and aged female rats are vulnerable to amygdala-dependent, but not hippocampus-dependent, memory impairment following short-term high-fat diet.Brain research bulletin · 2023Review
- Advances in optical molecular imaging for neural visualization.Frontiers in bioengineering and biotechnology · 2023Review
- PEX5R/Trip8b-HCN2 channel regulating neuroinflammation involved in perioperative neurocognitive disorders.Cell & bioscience · 2022Article
- The medial prefrontal cortex to the medial amygdala connections may affect the anxiety level in aged rats.Brain and behavior · 2022Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundAging changes brain function and behavior differently in male and female individuals. Changes in the medial prefrontal cortex (mPFC)-medial amygdala (MeA) connectivity affect anxiety-like behavior.
objectivesTherefore, this study aimed to investigate the effect of aging and sex on the mPFC-MeA connection and its association with the level of anxiety-like behavior.
methodsWe divided the Wistar rats into the male and female young rats (2-3-month-old) and male and female old rats (18-20 months old). First, the open field test (OFT) was performed, and then 80 nl of Fluoro-Gold (FG) was injected by stereotaxic surgery in the right or left MeA. After 10 days, the animals were perfused, their brain removed, coronal sections cut, and the number of FG-labeled cells in the right and left mPFC of each sample was estimated.
resultsBased on our results, old animals revealed less anxiety-like behavior than young ones, and young females were less anxious than young males, too. Interestingly, MeA of old male rats received more fibers from the bilateral mPFC than young ones. Also, this connection was stronger in the young females than young males. Altogether, the present study indicated that old individuals had less anxiety-like behavior and stronger mPFC-MeA connection, and young female rats were less anxious and had a stronger connection of mPFC-amygdala than males of the same age.
conclusionThus, it seems that there is a negative relationship between anxiety levels based on the rat's performance in the OFT apparatus and the mPFC-MeA connection.
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