Evidence map›Paper›PMID 35604799›Full record

ArticleACS applied materials & interfaces2022

Reconfigurable Microfluidic Circuits for Isolating and Retrieving Cells of Interest.

Cyril Deroy, James H R Wheeler, Agata N Rumianek, Peter R Cook, William M Durham, Kevin R Foster, Edmond J Walsh

Open access · hybridAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Suicidal chemotaxis in bacteria.Nature communications · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cyril DeroyDepartment of Engineering Science, Osney Thermo-Fluids Laboratory, University of Oxford, Oxford OX2 0ES, U.K.ORCID 0000-0001-8909-0847
James H R WheelerDepartment of Physics and Astronomy, University of Sheffield, Sheffield S3 7RH, U.K.
Agata N RumianekSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, U.K.
Peter R CookSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, U.K.
William M DurhamDepartment of Physics and Astronomy, University of Sheffield, Sheffield S3 7RH, U.K.
Kevin R FosterDepartment of Zoology, University of Oxford, Oxford OX1 3SZ, U.K.
Edmond J WalshDepartment of Engineering Science, Osney Thermo-Fluids Laboratory, University of Oxford, Oxford OX2 0ES, U.K.
University of Oxford · GB

Funding

Medical Research Council MC_PC_15029Wellcome Trust
6 · The paper itself

Abstract

Microfluidic devices are widely used in many fields of biology, but a key limitation is that cells are typically surrounded by solid walls, making it hard to access those that exhibit a specific phenotype for further study. Here, we provide a general and flexible solution to this problem that exploits the remarkable properties of microfluidic circuits with fluid walls─transparent interfaces between culture media and an immiscible fluorocarbon that are easily pierced with pipets. We provide two proofs of concept in which specific cell subpopulations are isolated and recovered: (i) murine macrophages chemotaxing toward complement component 5a and (ii) bacteria (

Indexed as

Microfluidic Analytical TechniquesMicrofluidicsAnimalsDiffusionLab-On-A-Chip DevicesMicePseudomonas aeruginosaantibiotic resistancecell isolationchemotaxisfluid wallsreconfigurable microfluidics

Identifiers

PMID35604799
PMCPMC9185686
OpenAlexW4281387253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.