Evidence map›Paper›PMID 35604784›Full record

ArticleACS biomaterials science & engineering2022

Structural Stability and Antigenicity of Universal Equine H3N8 Hemagglutinin Trimer upon Release from Polyanhydride Nanoparticles and Pentablock Copolymer Hydrogels.

Alaric C Siddoway, David Verhoeven, Kathleen A Ross, Michael J Wannemuehler, Surya K Mallapragada, Balaji Narasimhan

Open access · goldAbstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Safety and Biocompatibility of a Spray-Dried Influenza Microparticle Vaccine in Mice.Regenerative engineering and translational medicine · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Polyanhydride Chemistry.Biomacromolecules · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alaric C SiddowayDepartment of Chemical & Biological Engineering, Iowa State University, Ames, Iowa 50011, United States.
David VerhoevenDepartment of Veterinary Microbiology & Preventive Medicine, Iowa State University, Ames, Iowa 50011, United States.
Kathleen A RossNanovaccine Institute, Ames, Iowa 50011, United States.
Michael J WannemuehlerDepartment of Veterinary Microbiology & Preventive Medicine, Iowa State University, Ames, Iowa 50011, United States.
Surya K MallapragadaDepartment of Chemical & Biological Engineering, Iowa State University, Ames, Iowa 50011, United States.ORCID 0000-0002-9482-7273
Balaji NarasimhanDepartment of Chemical & Biological Engineering, Iowa State University, Ames, Iowa 50011, United States.ORCID 0000-0002-7955-5353
Iowa State University · US

Funding

Universal room temperature stable influenza nanovaccineR01AI141196 · NIAID · IOWA STATE UNIVERSITY · PI NARASIMHAN, BALAJI · 2019 to 2023
$5.6M
Combination nanovaccine-based immunization against influenza virus in the aged: immunity and protectionR01AI154458 · NIAID · IOWA STATE UNIVERSITY · PI KOHUT, MARIAN L, NARASIMHAN, BALAJI · 2021 to 2025
$3.5M
NIAID NIH HHS R01 AI141196NIAID NIH HHS R01 AI154458
6 · The paper itself

Abstract

Seasonal influenza A virus infections present substantial costs to both health and economic resources each year. Current seasonal influenza vaccines provide suboptimal protection and require annual reformulation to match circulating strains. In this work, a recombinant equine H3N8 hemagglutinin trimer (rH3

Indexed as

Influenza A virusInfluenza A Virus, H3N8 SubtypeNanoparticlesPolyanhydridesAnimalsAntibodies, ViralHemagglutininsHorsesHydrogelsAntibodies, ViralHemagglutininsHydrogelsPolyanhydrideshydrogelinfluenzananoparticlesPDEAEMpolyanhydride

Identifiers

PMID35604784
PMCPMC12108903
OpenAlexW4281291390

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.