ReviewEndocrine2022
Endocrine disrupting chemicals: effects on pituitary, thyroid and adrenal glands.
Review in Endocrine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Endocrine Disrupting Chemicals in Human Milk: A Systematic Review of Concentrations and Potential Health Implications.Current environmental health reports · 2025Pooled it
- Sex-Specific Thyroid Dysfunction in Sulfur Mustard-Exposed Veterans With Different Injury Severity.Journal of applied toxicology : JAT · 2026Article
- Review of in vitro approaches for assessing the toxicity of chemical stressors across diverse physiological systems.Toxicological sciences : an official journal of the Society of Toxicology · 2026Review
- Lessons from In Utero and Postnatal Exposure to Pesticide DDT: Mechanisms of Chromaffin Cell Vulnerability and Altered Catecholamine Homeostasis.International journal of molecular sciences · 2026Review
- The Thyroid Under Pressure: Heavy Metals, Endocrine Disruptors and Translational Insights into Carcinogenesis and Thyroid Dysfunctions.International journal of molecular sciences · 2026Review
- Environmental estrogens and animal reproductive health: mechanisms, biomarkers, and intervention approaches.Journal of animal science and biotechnology · 2026Review
- Signal Amplification in the HPT Axis-Evidence for Its Existence, Location, Significance, and Molecular Mechanisms.Acta physiologica (Oxford, England) · 2026Review
- Living in a chemical cocktail: real-world mixture exposures and their impact on ovarian function.The Journal of reproduction and development · 2026Review
- Associations of endocrine disrupting chemical biomarkers and their mixture with vitamin D biomarker concentrations in childhood: The HOME Study.Environmental research · 2026Article
- Maternal exposure to trace elements and perfluoroalkyl acids and their associations with alterations of the hypothalamic-pituitary-adrenal axis.Environmental research · 2025Article
- Towards molecular diagnostics of parental alienation.Cellular and molecular life sciences : CMLS · 2025Review
- Iron deficiency anemia in pregnancy and related complications with specific insight in Rivers State, Nigeria: a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Oestrogenic and androgenic activity of oxybenzone and methylparabenArhiv za higijenu rada i toksikologiju · 2025Article
- Review
- Effects of Endocrine-Disrupting Chemicals on Adrenal Function.Endocrinology · 2025Review
- Hematological and biochemical characterization of aging farm male rat strains in the national center for geriatrics and gerontology.Experimental animals · 2025Article
- Endocrine disrupting chemicals and the adrenal gland.Turkish journal of medical sciences · 2025Review
- Community-based insights into the connection between endocrine-disrupting chemicals and depressive symptoms.Current research in toxicology · 2025Article
- In-utero exposure to real-life environmental chemicals disrupts gene expression within the hypothalamo-pituitary-gonadal axis of prepubertal and adult rams.Environmental research · 2025Article
- CHIASMA: Advancing chemicals and materials safety and sustainability assessments through innovative integration of in vitro and in silico (new approach) methodologies.Computational and structural biotechnology journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years, scientific research has increasingly focused on Endocrine Disrupting Chemicals (EDCs) and demonstrated their relevant role in the functional impairment of endocrine glands. This induced regulatory authorities to ban some of these compounds and to carefully investigate others in order to prevent EDCs-related conditions. As a result, we witnessed a growing awareness and interest on this topic.
aimsThis paper aims to summarize current evidence regarding the detrimental effects of EDCs on pivotal endocrine glands like pituitary, thyroid and adrenal ones. Particularly, we directed our attention on the known and the hypothesized mechanisms of endocrine dysfunction brought by EDCs. We also gave a glimpse on recent findings from pioneering studies that could in the future shed a light on the pathophysiology of well-known, but poorly understood, endocrine diseases like hormone-producing adenomas.
conclusionsAlthough intriguing, studies on endocrine dysfunctions brought by EDCs are challenging, in particular when investigating long-term effects of EDCs on humans. However, undoubtedly, it represents a new intriguing field of science research.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.