Evidence map›Paper›PMID 35604365›Full record

ArticleHuman reproduction (Oxford, England)2022

Polygenic embryo screening: four clinical considerations warrant further attention.

S Pereira, S Carmi, G Altarescu, J Austin, D Barlevy, A Hershlag, E Juengst, K Kostick-Quenet, E Kovanci, R B Lathi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human reproduction (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Patient Perspectives on Psychiatric Polygenic Risk Scores in Reproductive Decision-Making and Polygenic Embryo Screening.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Polygenic embryo screening: quo vadis?Journal of assisted reproduction and genetics · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. A Call for Behavioral Science in Embedded Bioethics.Perspectives in biology and medicine · 2022
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

S PereiraCenter for Medical Ethics and Health Policy, Baylor College of Medicine, One Baylor Plaza, MS420, Houston, TX 77030, USA.ORCID 0000-0001-6541-3904
S CarmiBraun School of Public Health and Community Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
G AltarescuPreimplantation Genetic Unit and lysosomal Clinic, Medical Genetics Institute, Shaare Zedek Medical Center, Hebrew University, Jerusalem, Israel.ORCID 0000-0003-2796-8399
J AustinDepartments of Psychiatry and Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
D BarlevyCenter for Medical Ethics and Health Policy, Baylor College of Medicine, One Baylor Plaza, MS420, Houston, TX 77030, USA.
A HershlagRenaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
E JuengstCenter for Bioethics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
K Kostick-QuenetCenter for Medical Ethics and Health Policy, Baylor College of Medicine, One Baylor Plaza, MS420, Houston, TX 77030, USA.
E KovanciHouston Assisted Reproductive Technologies (HART) Fertility Clinic, The Woodlands, TX, USA.
R B LathiStanford University, Stanford, CA, USA.
M MukherjeeCenter for Medical Ethics and Health Policy, Baylor College of Medicine, One Baylor Plaza, MS420, Houston, TX 77030, USA.
I Van den VeyverDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, 77030, USA.
O ZukDepartment of Statistics and Data Science, The Hebrew University of Jerusalem, Jerusalem, Israel.
G Lázaro-MuñozCenter for Bioethics, Harvard Medical School, Boston, MA, USA.
T LenczDepartments of Psychiatry and Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.

Funding

Polygenic Embryo Screening: Towards Informed Decision-MakingR01HG011711 · NHGRI · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CARMI, SHAI, LAZARO-MUNOZ, GABRIEL · 2021 to 2025
$6.2M
NHGRI NIH HHS R01 HG011711
6 · The paper itself

Abstract

Recent advances in developing polygenic scores have made it possible to screen embryos for common, complex conditions and traits. Polygenic embryo screening (PES) is currently offered commercially, and though there has been much recent media and academic coverage, reproductive specialists' points of view have not yet been prominent in these discussions. We convened a roundtable of multidisciplinary experts, including reproductive specialists to discuss PES and its implications. In this Opinion, we describe four clinically relevant issues associated with the use of PES that have not yet been discussed in the literature and warrant consideration.

Indexed as

Mass ScreeningMultifactorial InheritanceAttentionEmbryo, MammalianGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPhenotypeembryo screeninggenetic screeninggenomic risk scorespolygenic embryo screeningpolygenic risk scoresPRStrait screening

Identifiers

PMID35604365
PMCPMC9247413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.