Evidence map›Paper›PMID 35604319›Full record

ArticleeLife2022

Dcp2 C-terminal

Feng He, Chan Wu, Allan Jacobson

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  15. Article
  16. Dcp2 C-terminaleLife · 2022
    Article
  17. Eukaryotic mRNA Decapping Activation.Frontiers in genetics · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Feng HeDepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, United States.ORCID 0000-0002-7523-2602
Chan WuDepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, United States.
Allan JacobsonDepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, United States.ORCID 0000-0002-5661-3821
University of Massachusetts Chan Medical School · US

Funding

Genetic nonsense and its consequencesR35GM122468 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI JACOBSON, ALLAN S · 2017 to 2021
$2.7M
NIGMS NIH HHS R35 GM122468
6 · The paper itself

Abstract

A single Dcp1-Dcp2 decapping enzyme targets diverse classes of yeast mRNAs for decapping-dependent 5' to 3' decay, but the molecular mechanisms controlling mRNA selectivity by the enzyme remain elusive. Through extensive genetic analyses we reveal that Dcp2 C-terminal domain

Indexed as

Saccharomyces cerevisiae ProteinsDEAD-box RNA HelicasesEndoribonucleasesNonsense Mediated mRNA DecayRibonucleoproteinsRNA-Binding ProteinsRNA, MessengerRNA StabilitySaccharomyces cerevisiaeDCP2 protein, S cerevisiaeDEAD-box RNA HelicasesDHH1 protein, S cerevisiaeEndoribonucleasesmRNA decapping enzymesPAT1 protein, S cerevisiaeRibonucleoproteinsRNA-Binding ProteinsRNA, MessengerSaccharomyces cerevisiae ProteinsScd6 protein, S cerevisiaechromosomesDcp2Edc3gene expressiongeneticsgenomicsNMDPat1S. cerevisiaeUpf1Xrn1

Identifiers

PMID35604319
PMCPMC9170289
OpenAlexW4281296605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.