Evidence map›Paper›PMID 35604282›Full record

ArticleDepression and anxiety2022

Neural markers of emotion regulation difficulties moderate effects of COVID-19 stressors on adolescent depression.

Resh S Gupta, Lindsay Dickey, Autumn Kujawa

Open access · greenAbstract read
In one paragraph

Article in Depression and anxiety, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Resh S GuptaDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.ORCID 0000-0003-2337-5473
Lindsay DickeyDepartment of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee, USA.
Autumn KujawaDepartment of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-0560-4589
Vanderbilt University · USUniversity of California San Diego · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
FELLOWSHIP IN GERIATRIC MENTAL HEALTHT32MH019934 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth W Twamley · 1994 to 2026
$9.5M
Identifying Neurophysiological Markers of Emotion Regulation Relevant to Adolescent Depression Diagnosis and Prognosis: A Comparison of Classification ModelsF31MH127863 · NIMH · VANDERBILT UNIVERSITY · PI DICKEY, LINDSAY · 2022 to 2024
$118k
The Effect of Mindfulness-Based Cognitive Therapy on ERP Markers of Attentional Bias in AnxietyF31AT010299 · NCCIH · VANDERBILT UNIVERSITY · PI GUPTA, RESH S. · 2019 to 2021
$79k
NCATS NIH HHS UL1 TR000445NCCIH NIH HHS F31 AT010299NCCIH NIH HHS F31AT010299NICHD NIH HHS P50 HD103537NIMH NIH HHS F31 MH127863NIMH NIH HHS T32 MH019934NIMH NIH HHS T32MH019934
6 · The paper itself

Abstract

backgroundStressful events, such as those imposed by the COVID-19 pandemic, are associated with depression risk, raising questions about processes that make some people more susceptible to the effects of stress on mental health than others. Emotion regulation may be a key process, but methods for objectively measuring emotion regulation abilities in youth are limited. We leveraged event-related potential (ERP) measures and a longitudinal study of adolescents oversampled for depression and depression risk to examine emotion regulation difficulties as prospective predictors of depressive symptoms in response to pandemic-related stress.

methodsBefore the pandemic, adolescents with (n = 28) and without (n = 34) clinical depression (N = 62 total) completed an explicit emotion regulation task while ERP data were recorded and measures of depressive symptoms. Adolescents were re-contacted during the pandemic to report on COVID-19 related stressful events and depressive symptoms (n = 48).

resultsAdolescents who had never experienced a depressive episode showed an increase in depressive symptoms during the pandemic, but adolescents who were clinically depressed before the pandemic did not exhibit significant changes in symptoms. Neural markers of emotion regulation abilities interacted with pandemic-related stressful events to predict depressive symptoms during the pandemic, such that stressors predicted increases in depressive symptoms only for adolescents with greater difficulty modulating responses to negative images before the pandemic.

conclusionsResults provide insight into adolescent mental health during the COVID-19 pandemic and highlight the role of emotion regulatory brain function in risk and resilience for depression.

Indexed as

COVID-19Emotional RegulationAdolescentDepressionEmotionsHumansLongitudinal StudiesPandemicsCOVID-19 pandemicdepressionemotion regulationevent-related potentialsstress

Identifiers

PMID35604282
PMCPMC9246973
OpenAlexW4281297525

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.