Evidence map›Paper›PMID 35604217›Full record

ArticleJournal of virology2022

Irreversible Loss of HIV-1 Proviral Competence in Myeloid Cells upon Suppression of NF-κB Activity.

Rebecca J Peters, Mario Stevenson

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rebecca J PetersDepartment of Microbiology and Immunology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
Mario StevensonDepartment of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
University of Miami · US

Funding

University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALLAN E RODRIGUEZ · 2007 to 2026
$33.8M
UC Davis Biostatistics CoreP01AI131568 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HARTIGAN-O'CONNOR, DENNIS J. · 2017 to 2021
$7.1M
Revealing HIV-1 persistence in myeloid cell reservoirsR01MH116701 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Mario Stevenson · 2018 to 2026
$4.0M
Relationship between methamphetamine use, viral reservoir dynamics and clinical progression in treated HIV infectionR01DA058437 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Adam Wayne Carrico, Mario Stevenson · 2023 to 2026
$2.6M
Defining a Role for Liver Myeloid Cells in Viral Persistence under ART-SUPPLEMENT 1R01DK131533 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Mario Stevenson, Emmanuel Thomas · 2022 to 2026
$2.5M
Defining brain pericytes as a novel and myeloid-derived HIV reservoirR01MH128022 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TOBOREK, MICHAL · 2021 to 2025
$2.3M
Irreversible Proviral Silencing in Myeloid CellsR21AI172772 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI STEVENSON, MARIO · 2023 to 2024
$422k
NIAID NIH HHS P01 AI131568NIAID NIH HHS P30 AI073961NIAID NIH HHS R21 AI172772NIDA NIH HHS R01 DA058437NIDDK NIH HHS R01 DK131533NIMH NIH HHS R01 MH116701NIMH NIH HHS R01 MH128022
6 · The paper itself

Abstract

Although antiretroviral therapy (ART) sustains potent suppression of plasma viremia in people with HIV-1 infection (PWH), reservoirs of viral persistence rekindle viral replication and viremia if ART is halted. Understanding the nature of viral reservoirs and their persistence mechanisms remains fundamental to further research aiming to eliminate them and achieve ART-free viral remission or virological cure. CD4

Indexed as

HIV-1HIV InfectionsMyeloid CellsProvirusesVirus LatencyCD4-Positive T-LymphocytesHumansNF-kappa BViremiaNF-kappa BHIV-1latencyMDMmyeloid cells

Identifiers

PMID35604217
PMCPMC9215224
OpenAlexW4281291026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.