Evidence map›Paper›PMID 35603919›Full record

SynthesisDiabetes, obesity & metabolism2022

The impact of the COVID-19 pandemic on glycaemic control in people with diabetes: A systematic review and meta-analysis.

Lauren L O'Mahoney, Patrick J Highton, Laura Kudlek, Jessica Morgan, Rosie Lynch, Ella Schofield, Nayanika Sreejith, Ajay Kapur, Afolarin Otunla, Sven Kerneis and 5 more

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Diabetes, obesity & metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Observational
  4. Leveraging Machine Learning to Assess Post-COVID-19 Glycemic Control in Diabetic Patients.International journal of environmental research and public health · 2026
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  20. Sustained Improvement in Glycemic Control in Emerging Adults with Type 1 Diabetes 2 Years After the Start of the COVID-19 Pandemic.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Lauren L O'MahoneyDiabetes Research Centre, University of Leicester, Leicester, UK.ORCID 0000-0002-2786-3290
Patrick J HightonDiabetes Research Centre, University of Leicester, Leicester, UK.ORCID 0000-0002-0410-5788
Laura KudlekNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.ORCID 0000-0003-0947-3640
Jessica MorganMedical Sciences Division, University of Oxford, Oxford, UK.ORCID 0000-0002-2849-6672
Rosie LynchMedical Sciences Division, University of Oxford, Oxford, UK.
Ella SchofieldMedical Sciences Division, University of Oxford, Oxford, UK.ORCID 0000-0003-2332-5185
Nayanika SreejithMedical Sciences Division, University of Oxford, Oxford, UK.ORCID 0000-0002-0946-3904
Ajay KapurMedical Sciences Division, University of Oxford, Oxford, UK.ORCID 0000-0002-5104-6629
Afolarin OtunlaMedical Sciences Division, University of Oxford, Oxford, UK.ORCID 0000-0002-9091-7853
Sven KerneisMedical Sciences Division, University of Oxford, Oxford, UK.ORCID 0000-0002-9683-2295
Olivia JamesMedical Sciences Division, University of Oxford, Oxford, UK.
Karen ReesFreelance Systematic Reviewer, Warwickshire, UK.ORCID 0000-0003-1832-3679
Ffion CurtisDiabetes Research Centre, University of Leicester, Leicester, UK.ORCID 0000-0001-6843-8568
Kamlesh KhuntiDiabetes Research Centre, University of Leicester, Leicester, UK.ORCID 0000-0003-2343-7099
Jamie Hartmann-BoyceNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.ORCID 0000-0001-9898-3049
University of Oxford · GBUniversity of Leicester · GBKleijnen Systematic Reviews (United Kingdom) · GB

Funding

Department of Health
6 · The paper itself

Abstract

aimTo identify, appraise and synthesize the available evidence on the impact of the coronavirus disease 2019 (COVID-19) pandemic and lockdown (LD) on glycaemic control in people with diabetes. MATERIALS AND

methodsWe searched multiple databases up to 2 February 2021 for studies reporting HbA1c, time in range (TIR), average or fasting glucose, severe hypoglycaemia and diabetic ketoacidosis. Data were pooled using random effects meta-analysis and are presented as mean difference (MD) with 95% confidence intervals (CI). This review was preregistered on PROSPERO (CRD42020179319).

resultsWe include 59 studies; 44 (n = 15 464) were included in quantitative syntheses and 15 were narratively synthesized. Pooled data were grouped by diabetes type. Results from 28 studies (n = 5048 type 1 diabetes [T1D] and combined diabetes participants) showed that TIR increased during LD compared with before LD (MD 2.74%, 95% CI 1.80% to 3.69%). Data from 10 studies (n = 1294 T1D participants) showed that TIR increased after LD compared with before LD (MD 5.14%, 95% CI 3.12% to 7.16%). Pooled results from 12 studies (n = 4810 T1D and type 2 diabetes participants) resulted in average glucose decreasing after LD compared with before LD (MD -6.86 mg/dl, 95% CI -8.54 to -5.18). Results for other outcomes, including HbA1c, were not statistically significantly different.

conclusionsThe COVID-19 pandemic was associated with small improvements across multiple outcomes of glycaemic control, although there was insufficient evidence to suggest that this led to changes in HbA1c. Most evidence came from people with access to diabetes technologies in high-income countries; more research is needed in less advantaged populations.

Indexed as

COVID-19Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Communicable Disease ControlGlucoseGlycated HemoglobinGlycemic ControlHumansPandemicsGlucoseGlycated Hemoglobincontinuous glucose monitoringsystematic reviewtype 1 diabetestype 2 diabetes

Identifiers

PMID35603919
PMCPMC9347483
OpenAlexW4281294952

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.