Evidence map›Paper›PMID 35603560›Full record

ArticlemSphere2022

The Tyrosine Phosphatase PRL Regulates Attachment of Toxoplasma gondii to Host Cells and Is Essential for Virulence.

Chunlin Yang, William J Blakely, Gustavo Arrizabalaga

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chunlin YangDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
William J BlakelyDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Gustavo ArrizabalagaDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-4445-0375
Indiana University School of Medicine

Funding

Training In Tumor VirologyT32CA115299 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ROBERTSON, ERLE S. · 2006 to 2021
$4.7M
Dissecting the calcium dependent phosphorylation network of Toxoplasma gondiiR01AI123457 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI ARRIZABALAGA, GUSTAVO A, TREECK, MORITZ · 2016 to 2020
$2.7M
Interleukin-1 and Steroid Signaling Drive Toxoplasma-induced Prostatic HyperplasiaR01DK124067 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI ARRIZABALAGA, GUSTAVO A, JERDE, TRAVIS J · 2020 to 2023
$2.1M
Regulation of mitochondrial morphodynamics in Toxoplasma gondiiR01AI149766 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ARRIZABALAGA, GUSTAVO A · 2020 to 2024
$2.0M
NCI NIH HHS T32 CA115299NIAID NIH HHS R01 AI123457NIAID NIH HHS R01 AI149766NIDDK NIH HHS R01 DK124067
6 · The paper itself

Abstract

The pathogenesis of Toxoplasma gondii is mainly due to tissue damage caused by the repeating lytic cycles of the parasite. Many proteins localized to the pellicle of the parasite, particularly kinases, have been identified as critical regulators of the

Indexed as

ToxoplasmaAnimalsHumansLiverMammalsMicePhosphoprotein PhosphatasesProtozoan ProteinsTyrosineVirulencePhosphoprotein PhosphatasesProtozoan ProteinsTyrosineattachmentmagnesiumparasitePRLToxoplasmatyrosine phosphatasevirulence

Identifiers

PMID35603560
PMCPMC9241511
OpenAlexW4281293946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.