Evidence map›Paper›PMID 35603305›Full record

ArticleCommunications medicine2022

German federal-state-wide seroprevalence study of 1

Stefan Lohse, Anna Sternjakob-Marthaler, Paul Lagemann, Jakob Schöpe, Jürgen Rissland, Nastasja Seiwert, Thorsten Pfuhl, Alana Müllendorff, Laurent S Kiefer, Markus Vogelgesang and 14 more

Open access · goldAbstract read
In one paragraph

Article in Communications medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Dynamics of SARS-CoV-2 seroassay sensitivity: a systematic review and modelling study.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Pooled it
  2. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 2 countries.

Stefan Lohse *Institute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.ORCID 0000-0003-2529-1900
Anna Sternjakob-Marthaler *Institute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.
Paul LagemannInstitute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.
Jakob SchöpeInstitute for Medical Biometry, Epidemiology and Medical Informatics, Saarland University Medical Center, 66421 Homburg, Germany.
Jürgen RisslandInstitute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.
Nastasja SeiwertInstitute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.
Thorsten PfuhlInstitute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.
Alana MüllendorffInstitute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.
Laurent S KieferInstitute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.
Markus VogelgesangInstitute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.
Luca VellaInstitute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.
Katharina DenkInstitute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.
Julia VicariInstitute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.
Anabel ZwickInstitute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.
Isabelle LangInstitute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.ORCID 0000-0002-6111-8884
Gero WeberPhysical Geography and Environmental Research, Saarland University, 66125 Saarbrücken, Germany.
Jürgen GeiselCentral Laboratory, Saarland University Hospital, 66421 Homburg, Germany.
Jörg RechMinistry of Health, Social Affairs, Women and the Family, 66119 Saarbrücken, Germany.
Bernd SchnabelMinistry of Health, Social Affairs, Women and the Family, 66119 Saarbrücken, Germany.
Gunter HauptmannKassenärztliche Vereinigung Saarland, 66113 Saarbrücken, Germany.
Bernd HolleczekMinistry of Health, Social Affairs, Women and the Family, 66119 Saarbrücken, Germany.
Heinrich ScheiblauerPaul-Ehrlich-Institut, 63225 Langen, Germany.
Stefan WagenpfeilInstitute for Medical Biometry, Epidemiology and Medical Informatics, Saarland University Medical Center, 66421 Homburg, Germany.ORCID 0000-0002-4558-4041
Sigrun SmolaInstitute of Virology, Saarland University Medical Center, 66421 Homburg, Germany.
Saarland University · DEMinistry of Internal Affairs of the Republic of Tajikistan · TJHelmholtz Centre for Infection Research · DEKassenärztliche Vereinigung Baden-Württemberg · DEPaul Ehrlich Institut · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Reliable data on the adult SARS-CoV-2 infection fatality rate in Germany are still scarce. We performed a federal state-wide cross-sectional seroprevalence study named SaarCoPS, that is representative for the adult population including elderly individuals and nursing home residents in the Saarland. Methods: Serum was collected from 2940 adults via stationary or mobile teams during the 1 Results: Using a highly specific total antibody test detecting anti-SARS-CoV-2 responses over more than 180 days, we estimate an adult infection rate of 1.02% (95% CI: [0.64; 1.44]), an underreporting rate of 2.68-fold (95% CI: [1.68; 3.79]) and infection fatality rates of 2.09% (95% CI: (1.48; 3.32]) or 0.36% (95% CI: [0.25; 0.59]) in all adults including elderly individuals, or adults younger than 70 years, respectively. Conclusion: The study highlights the importance of study design and test performance for seroprevalence studies, particularly when seroprevalences are low. Our results provide a valuable baseline for evaluation of future pandemic dynamics and impact of public health measures on virus spread and human health in comparison to neighbouring countries such as Luxembourg or France.

Indexed as

Population screeningViral infection

Identifiers

PMID35603305
PMCPMC9117207
OpenAlexW4280572340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.