ArticleCommunications medicine2022
Development and preliminary validation of infrared spectroscopic device for transdermal assessment of elevated cardiac troponin.
Article in Communications medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A Wearable Infrared Sensor for Detecting Non-ST Segment Elevation Acute Coronary Syndromes.Life (Basel, Switzerland) · 2026Article
- Wearable technologies in clinical trials for drug development: trends and emerging opportunities.Nature reviews. Drug discovery · 2026Review
- Minimally Invasive and in Situ Capacitive Sensing of Cardiac Troponin I from Interstitial Fluid.ACS sensors · 2025Article
- A rapid noninvasive wearable device for assessing cardiac troponin I level.Clinical and experimental emergency medicine · 2025Article
- Utilizing saliva for non-invasive detection of exercise-induced myocardial injury with point-of-care cardiac troponin-I.Scientific reports · 2025Article
- Update on Patient Self-Testing with Portable and Wearable Devices: Advantages and Limitations.Diagnostics (Basel, Switzerland) · 2024Article
- Visions for digital integrated cardiovascular care: HRS Digital Health Committee perspectives.Cardiovascular digital health journal · 2024Article
- Serial troponin-I and long-term outcomes in subjects with suspected acute coronary syndrome.European journal of preventive cardiology · 2024Article
- Clinical Biochemistry of Serum Troponin.Diagnostics (Basel, Switzerland) · 2024Review
- Progress in the Optical Sensing of Cardiac Biomarkers.Biosensors · 2023Review
- Infrared spectral analysis for the classification of patients with acute coronary syndrome. The questions run so deep.European heart journal. Digital health · 2023Article
- A novel breakthrough in wrist-worn transdermal troponin-I-sensor assessment for acute myocardial infarction.European heart journal. Digital health · 2023Article
- Early Changes in Acute Myocardial Infarction in Pigs: Achieving Early Detection with Wearable Devices.Diagnostics (Basel, Switzerland) · 2023Article
- Development and preliminary validation of infrared spectroscopic device for transdermal assessment of elevated cardiac troponin.Communications medicine · 2022Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The levels of circulating troponin are principally required in addition to electrocardiograms for the effective diagnosis of acute coronary syndrome. Current standard-of-care troponin assays provide a snapshot or momentary view of the levels due to the requirement of a blood draw. This modality further restricts the number of measurements given the clinical context of the patient. In this communication, we present the development and early validation of non-invasive transdermal monitoring of cardiac troponin-I to detect its elevated state. Methods: Our device relies on infrared spectroscopic detection of troponin-I through the dermis and is tested in stepwise laboratory, benchtop, and clinical studies. Patients were recruited with suspected acute coronary syndrome. Results: We demonstrate a significant correlation ( Conclusion: This preliminary work introduces the potential of a bloodless transdermal measurement of troponin-I based on molecular spectroscopy. Further, potential pitfalls associated with infrared spectroscopic mode of inquiry are outlined including requisite steps needed for improving the precision and overall diagnostic value of the device in future studies.
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