Evidence map›Paper›PMID 35603288›Full record

ArticleCommunications medicine2022

Association of physical activity and sleep habits during pregnancy with autistic spectrum disorder in 3-year-old infants.

Kazushige Nakahara, Takehiro Michikawa, Seiichi Morokuma, Norio Hamada, Masanobu Ogawa, Kiyoko Kato, Masafumi Sanefuji, Eiji Shibata, Mayumi Tsuji, Masayuki Shimono and 4 more

Abstract read
In one paragraph

Article in Communications medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kazushige Nakahara *Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0001-5458-6375
Takehiro Michikawa *Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo, Japan.
Seiichi MorokumaDepartment of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0001-5995-0017
Norio HamadaDepartment of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0002-0906-8277
Masanobu OgawaDepartment of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kiyoko KatoDepartment of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Masafumi SanefujiResearch Center for Environment and Developmental Medical Sciences, Kyushu University, Fukuoka, Japan.
Eiji ShibataRegional Center for Japan Environment and Children's Study (JECS), University of Occupational and Environmental Health, Kitakyushu, Japan.
Mayumi TsujiRegional Center for Japan Environment and Children's Study (JECS), University of Occupational and Environmental Health, Kitakyushu, Japan.
Masayuki ShimonoRegional Center for Japan Environment and Children's Study (JECS), University of Occupational and Environmental Health, Kitakyushu, Japan.
Toshihiro KawamotoRegional Center for Japan Environment and Children's Study (JECS), University of Occupational and Environmental Health, Kitakyushu, Japan.
Shouichi OhgaResearch Center for Environment and Developmental Medical Sciences, Kyushu University, Fukuoka, Japan.
Koichi KusuharaRegional Center for Japan Environment and Children's Study (JECS), University of Occupational and Environmental Health, Kitakyushu, Japan.
Japan Environment and Children’s Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We hypothesized that maternal lifestyle factors, such as physical activity and sleep habits, may be associated with autism spectrum disorder (ASD) in infants. This study aimed to investigate the association between maternal physical activity and sleep before and during pregnancy with infant ASD diagnosed by the age of 3 years. Methods: We used the data from the Japan Environment and Children's Study between 2011 and 2014. The study included 103,060 pregnant women, among which, 69,969 women were analyzed. Participants were asked about their physical activity and sleep before and during pregnancy using questionnaires during pregnancy. Maternal physical activity was estimated using the international physical activity questionnaire. Based on the levels of physical activity before or during pregnancy, the participants were divided into five groups. Maternal sleep was analyzed based on sleep duration and bedtime. The outcome was diagnosis of ASD in 3-year-old infants. Results: In mothers with higher physical activity levels during pregnancy, the risk ratios (RR) for ASD in their 3-year-old infants were lower (RR = 0.61, 95% confidence interval (CI) = 0.42-0.90). In contrast, too short (<6 h) and too long (>10 h) sleep durations during pregnancy were associated with higher risk ratios for ASD than 7-8 h sleep duration (too short: RR = 1.87, 95% CI = 1.21-2.90; too long: RR = 1.56, 95% CI = 1.00-2.48). These associations were not observed before pregnancy. Conclusion: Maternal physical activity and sleep duration during pregnancy may be associated with ASD in infants.

Indexed as

Autism spectrum disordersEpidemiologyPaediatric research

Identifiers

PMID35603288
PMCPMC9053216

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.