Evidence map›Paper›PMID 35603279›Full record

ArticleCommunications medicine2022

Identifying causal relationships of cancer treatment and long-term health effects among 5-year survivors of childhood cancer in Southern Sweden.

Anders Holst, Jan Ekman, Magnus Petersson-Ahrholt, Thomas Relander, Thomas Wiebe, Helena M Linge

Open access · goldAbstract read
In one paragraph

Article in Communications medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Anders HolstDepartment of Computer Science, Division of Digital Systems, Research Institutes of Sweden, Stockholm, Sweden.ORCID 0000-0001-8577-6745
Jan EkmanDepartment of Computer Science, Division of Digital Systems, Research Institutes of Sweden, Stockholm, Sweden.ORCID 0000-0002-7181-8411
Magnus Petersson-AhrholtClimber, Malmo, Sweden.ORCID 0000-0003-4483-1810
Thomas RelanderDepartment of Clinical Sciences Lund, Oncology, Skane University Hospital, Lund University, Lund, Sweden.
Thomas WiebeDepartment of Clinical Sciences Lund, Pediatrics, Faculty of Medicine, Lund University, Lund, Sweden.
Helena M LingeDepartment of Clinical Sciences Lund, Pediatrics, Faculty of Medicine, Lund University, Lund, Sweden.ORCID 0000-0002-8919-0300
Lund University · SERISE Research Institutes of Sweden · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Survivors of childhood cancer can develop adverse health events later in life. Infrequent occurrences and scarcity of structured information result in analytical and statistical challenges. Alternative statistical approaches are required to investigate the basis of late effects in smaller data sets. Methods: Here we describe sex-specific health care use, mortality and causal associations between primary diagnosis, treatment and outcomes in a small cohort ( Results: Our results confirm a significantly higher health care usage and premature mortality among childhood cancer survivors as compared to controls. The developed method for causal inference identifies 98 significant associations ( Conclusions: The findings contribute to a broader understanding of the consequences of cancer treatment. The study shows relevance for small data sets and causal inference, and presents the method as a complement to traditional statistical approaches.

Indexed as

DatabasesPaediatric cancer

Identifiers

PMID35603279
PMCPMC9053221
OpenAlexW4214849278

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.