Evidence map›Paper›PMID 35603231›Full record

ArticleBioinformatics advances2022

Pollock: fishing for cell states.

Erik P Storrs, Daniel Cui Zhou, Michael C Wendl, Matthew A Wyczalkowski, Alla Karpova, Liang-Bo Wang, Yize Li, Austin Southard-Smith, Reyka G Jayasinghe, Lijun Yao and 10 more

Abstract read
In one paragraph

Article in Bioinformatics advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Mapping Cell Identity from scRNA-seq: A primer on computational methods.Computational and structural biotechnology journal · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Erik P StorrsDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Daniel Cui ZhouDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Michael C WendlDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Matthew A WyczalkowskiDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Alla KarpovaDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0003-0467-0215
Liang-Bo WangDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Yize LiDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0003-1074-281X
Austin Southard-SmithDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Reyka G JayasingheDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Lijun YaoDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Ruiyang LiuDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Yige WuDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Nadezhda V TerekhanovaDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Houxiang ZhuDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
John M HerndonDepartment of Surgery, Washington University in St. Louis, St. Louis, MO 63110, USA.
Sid PuramDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Feng ChenDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
William E GillandersDepartment of Surgery, Washington University in St. Louis, St. Louis, MO 63110, USA.
Ryan C FieldsDepartment of Surgery, Washington University in St. Louis, St. Louis, MO 63110, USA.
Li DingDepartment of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0003-1517-2975

Funding

WASHINGTON UNIVERSITY HUMAN TUMOR ATLAS RESEARCH CENTERU2CCA233303 · NCI · WASHINGTON UNIVERSITY · PI DING, LI, FIELDS, RYAN C · 2018 to 2023
$9.7M
INSTITUTIONAL TRAINING GRANT IN GENOMIC SCIENCET32HG000045 · NHGRI · WASHINGTON UNIVERSITY · PI MICHAEL R BRENT, Barak A Cohen · 1997 to 2026
$8.4M
NCI NIH HHS U2C CA233303NHGRI NIH HHS T32 HG000045
6 · The paper itself

Abstract

Motivation: The use of single-cell methods is expanding at an ever-increasing rate. While there are established algorithms that address cell classification, they are limited in terms of cross platform compatibility, reliance on the availability of a reference dataset and classification interpretability. Here, we introduce Pollock, a suite of algorithms for cell type identification that is compatible with popular single-cell methods and analysis platforms, provides a set of pretrained human cancer reference models, and reports interpretability scores that identify the genes that drive cell type classifications. Results: Pollock performs comparably to existing classification methods, while offering easily deployable pretrained classification models across a wide variety of tissue and data types. Additionally, it demonstrates utility in immune pan-cancer analysis. Availability and implementation: Source code and documentation are available at https://github.com/ding-lab/pollock. Pretrained models and datasets are available for download at https://zenodo.org/record/5895221. Supplementary information: Supplementary data are available at

Identifiers

PMID35603231
PMCPMC9115775

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.