Evidence map›Paper›PMID 35603230›Full record

ArticleAdvanced functional materials2022

Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks.

Ren Liu, Jihwan Lee, Youngbin Tchoe, Deborah Pre, Andrew M Bourhis, Agnieszka D'Antonio-Chronowska, Gaelle Robin, Sang Heon Lee, Yun Goo Ro, Ritwik Vatsyayan and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ren LiuIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Jihwan LeeIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Youngbin TchoeIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Deborah PreConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Andrew M BourhisIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Agnieszka D'Antonio-ChronowskaDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Gaelle RobinConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Sang Heon LeeIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Yun Goo RoIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Ritwik VatsyayanIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Karen J TonsfeldtIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Center for Reproductive Science and Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Lorraine A HossainIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
M Lisa PhippsCenter for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Jinkyoung YooCenter for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
John NoganCenter for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, NM 87185, USA.
Jennifer S MartinezCenter for Materials Interfaces in Research and Applications and Department of Applied Physics and Materials Science, Northern Arizona University, 624 S. Knoles Dr. Flagstaff, AZ 86011.
Kelly A FrazerDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Anne G BangConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Shadi A DayehIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Funding

Thin, High-Density, High-Performance, Depth and Surface Microelectrodes for Diagnosis and Treatment of EpilepsyUG3NS123723 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2021 to 2025
$9.5M
Bringing Light to Functional Mapping in Resective NeurosurgeryDP2EB029757 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2019 to 2019
$2.4M
Integration of High Definition Display Technologies with Platinum Nanorod Microelectrodes for Large Scale in-vivo Recording and StimulationR01NS123655 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2021 to 2021
$2.0M
NIBIB NIH HHS DP2 EB029757NINDS NIH HHS R01 NS123655NINDS NIH HHS UG3 NS123723
6 · The paper itself

Abstract

We report innovative scalable, vertical, ultra-sharp nanowire arrays that are individually addressable to enable long-term, native recordings of intracellular potentials. Stable amplitudes of intracellular potentials from 3D tissue-like networks of neurons and cardiomyocytes are obtained. Individual electrical addressability is necessary for high-fidelity intracellular electrophysiological recordings. This study paves the way toward predictive, high-throughput, and low-cost electrophysiological drug screening platforms.

Indexed as

cardiomyocytecultureintracellularnanowireneurontissue

Identifiers

PMID35603230
PMCPMC9122115

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.