Evidence map›Paper›PMID 35603192›Full record

ArticleFrontiers in immunology2022

T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center Response and T Helper Cell Differentiation.

Annika C Betzler, Jasmin Ezić, Tsima Abou Kors, Thomas K Hoffmann, Thomas Wirth, Cornelia Brunner

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Role of the Transcriptional Coactivator BOB.1/OBF.1 in Adaptive Immunity.Advances in experimental medicine and biology · 2024
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Annika C BetzlerDepartment of Oto-Rhino-Laryngology, Ulm University Medical Center, Ulm, Germany.
Jasmin EzićDepartment of Oto-Rhino-Laryngology, Ulm University Medical Center, Ulm, Germany.
Tsima Abou KorsDepartment of Oto-Rhino-Laryngology, Ulm University Medical Center, Ulm, Germany.
Thomas K HoffmannDepartment of Oto-Rhino-Laryngology, Ulm University Medical Center, Ulm, Germany.
Thomas WirthDepartment of Physiological Chemistry, Ulm University, Ulm, Germany.
Cornelia BrunnerDepartment of Oto-Rhino-Laryngology, Ulm University Medical Center, Ulm, Germany.
Universität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcriptional co-activator BOB.1/OBF.1 is expressed in both B and T cells. The main characteristic of conventional BOB.1/OBF.1 deficient mice is the complete absence of germinal centers (GCs). This defect was mainly attributed to the defective B cell compartment. However, it is unknown whether and how BOB.1/OBF.1 expression in T cells contributes to the GC reaction. To finally clarify this question, we studied the

Indexed as

Germinal CenterLymphocyte ActivationAnimalsB-LymphocytesCell DifferentiationMiceTrans-ActivatorsTranscription FactorsPou2af1 protein, mouseTrans-ActivatorsTranscription FactorsBOB.1/OBF.1follicular T helper cellsgerminal centerhumoral immunityPou2af1T cell differentiationtranscriptional co-activator

Identifiers

PMID35603192
PMCPMC9114770
OpenAlexW4225388981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.