ReviewFrontiers in immunology2022
Current Understanding of Long-Term Cognitive Impairment After Sepsis.
Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- The core role of central nervous system in sepsis-related organ damage.Frontiers in immunology · 2025Pooled it
- Impact of neonatal sepsis on neurocognitive outcomes: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- A Systematic Review of Semaglutide's Influence on Cognitive Function in Preclinical Animal Models and Cell-Line Studies.International journal of molecular sciences · 2024Pooled it
- Neuroinflammation as a Final Common Pathway in Systemic Disease - How Systemic Disease Becomes Brain Disease.Current neurology and neuroscience reports · 2026Review
- Cognitive assessment in children with intestinal failure on and weaned off parenteral nutrition.Journal of pediatric gastroenterology and nutrition · 2026Observational
- Longitudinal Cognitive Recovery After Critical Illness: Trajectories in Sepsis and Non-Sepsis Survivors.Journal of intensive care medicine · 2026Article
- Trajectories of sepsis survivors in Australia: A scoping review.Journal of the Intensive Care Society · 2026Article
- Measuring health-related quality of life in sepsis survivors and caregivers: a mapping review and a preliminary conceptual framework.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Review
- Effects of Lactate on Improving Cognitive Function and Survival Rate in a Mouse Model of Post-Sepsis Cognitive Impairment.Actas espanolas de psiquiatria · 2026Article
- Neuropathologic Autopsy Findings in Pediatric Sepsis: A Two-Center, Retrospective Study.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026Article
- Systemic Inflammation Aggravates Retinal Ganglion Cell Vulnerability to Optic Nerve Trauma in Adult Rats.International journal of molecular sciences · 2026Article
- Frontal, temporal, cerebellar changes link to sepsis survivors' cognitive issues: A resting state functional magnetic resonance imaging study.World journal of psychiatry · 2025Article
- Longitudinal Cognitive Recovery in Survivors of Critical Illness: Impact of Sepsis and Benzodiazepine Exposure.medRxiv : the preprint server for health sciences · 2025Article
- The Impact of Neonatal Sepsis on Long-Term Neurodevelopment: A Systematic Review of Cognitive and Sensory Outcomes.Cureus · 2025Review
- Convergence of sepsis-associated encephalopathy pathogenesis onto microglia.Journal of translational medicine · 2025Review
- Evaluating Sepsis Management and Patient Outcomes: A Comprehensive Retrospective Study of Clinical and Treatment Data.Journal of clinical medicine · 2025Article
- Improving Outcomes in Survivors of Sepsis-The Transition from Secondary to Primary Care, and the Role of Primary Care: A Narrative Review.Journal of clinical medicine · 2025Review
- Review on the Role of Mitochondrial Dysfunction in Septic Encephalopathy.Cell biochemistry and biophysics · 2025Review
- Postoperative sepsis and its sequential impact on dementia.Critical care (London, England) · 2025Article
- Development and validation of an interpretable machine learning model for predicting cognitive impairment in patients with sepsis.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is recognized as a life-threatening multi-organ dysfunction resulting from a dysregulated host response to infection. Although the incidence and mortality of sepsis decrease significantly due to timely implementation of anti-infective and support therapies, accumulating evidence suggests that a great proportion of survivors suffer from long-term cognitive impairment after hospital discharge, leading to decreased life quality and substantial caregiving burdens for family members. Several mechanisms have been proposed for long-term cognitive impairment after sepsis, which are not mutually exclusive, including blood-brain barrier disruption, neuroinflammation, neurotransmitter dysfunction, and neuronal loss. Targeting these critical processes might be effective in preventing and treating long-term cognitive impairment. However, future in-depth studies are required to facilitate preventive and/or treatment strategies for long-term cognitive impairment after sepsis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.