Evidence map›Paper›PMID 35603143›Full record

ArticleFrontiers in immunology2022

Ethanol Intoxication Impairs Respiratory Function and Bacterial Clearance and Is Associated With Neutrophil Accumulation in the Lung After

Holly J Hulsebus, Kevin M Najarro, Rachel H McMahan, Devin M Boe, David J Orlicky, Elizabeth J Kovacs

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Alcohol's Effects on the Lung and Lung Disease.Alcohol research : current reviews · 2025
    Pooled it
  2. Review
  3. Adolescent trauma and alcohol: increased risk for severe head injury and organ dysfunction-insights from the TraumaRegister DGUEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Article
  4. Post-burn Lung Inflammation Is Associated With Induction of Pulmonary Cathelicidin-related Antimicrobial Peptide and S100a8 in Mice.Journal of burn care & research : official publication of the American Burn Association · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Holly J HulsebusDepartment of Surgery, Division of GI, Trauma and Endocrine Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Kevin M NajarroDepartment of Surgery, Division of GI, Trauma and Endocrine Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Rachel H McMahanDepartment of Surgery, Division of GI, Trauma and Endocrine Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Devin M BoeDepartment of Surgery, Division of GI, Trauma and Endocrine Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
David J OrlickyDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Elizabeth J KovacsDepartment of Surgery, Division of GI, Trauma and Endocrine Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
University of Colorado Anschutz Medical Campus · US

Funding

Aging, macrophage mediators, and burn trauma: SupplementR01AG018859 · NIA · UNIVERSITY OF COLORADO DENVER · PI KOVACS, ELIZABETH J. · 2001 to 2024
$7.6M
Alcohol and Burn Trauma: Multi-organ Inflammatory ResponsesR35GM131831 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI ELIZABETH J. KOVACS · 2019 to 2026
$3.5M
Alcohol and Lung Immunity in the AgedR21AA026295 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI KOVACS, ELIZABETH J. · 2018 to 2019
$408k
Binge alcohol intoxication, mesenchymal stem cells and lung inflammationR21AA023193 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI KOVACS, ELIZABETH J. · 2015 to 2016
$402k
Ethanol effects on pulmonary innate immunity in a murine model of agingF31AA027687 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI HULSEBUS, HOLLY J · 2019 to 2021
$101k
Multi-organ Inflammatory Responses after Burn TraumaI01BX004335 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI KOVACS, ELIZABETH J. · 2019 to 2023
–
BLRD VA I01 BX004335NIAAA NIH HHS F31 AA027687NIAAA NIH HHS R21 AA023193NIAAA NIH HHS R21 AA026295NIA NIH HHS R01 AG018859NIGMS NIH HHS R35 GM131831
6 · The paper itself

Abstract

Alcohol consumption is commonplace in the United States and its prevalence has increased in recent years. Excessive alcohol use is linked to an increased risk of infections including pneumococcal pneumonia, mostly commonly caused by

Indexed as

Alcoholic IntoxicationPneumococcal InfectionsPneumonia, PneumococcalAnimalsChemokinesEthanolHumansLungMiceNeutrophilsStreptococcus pneumoniaeChemokinesEthanolalcoholinflammationinnate immunityleukocytelung functionmacrophage

Identifiers

PMID35603143
PMCPMC9116899
OpenAlexW4225380101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.