Evidence map›Paper›PMID 35603139›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2022

Differential diagnostic performance of a panel of plasma biomarkers for different types of dementia.

Elisabeth H Thijssen, Inge M W Verberk, Jana Kindermans, Adlin Abramian, Jeroen Vanbrabant, Andrew J Ball, Yolande Pijnenburg, Afina W Lemstra, Wiesje M van der Flier, Erik Stoops and 2 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. [Progress on prognostic assessment methods for mild cognitive impairment].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
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  17. Alzheimer's disease plasma biomarkers in the Midwestern Amish.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  18. Article
  19. Article
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elisabeth H ThijssenNeurochemistry Laboratory Department of Clinical Chemistry Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC Amsterdam the Netherlands.
Inge M W VerberkNeurochemistry Laboratory Department of Clinical Chemistry Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC Amsterdam the Netherlands.
Jana KindermansIRMB-PPC, INM, Univ Montpellier, CHU Montpellier, INSERM CNRS Montpellier France.
Adlin AbramianNeurochemistry Laboratory Department of Clinical Chemistry Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC Amsterdam the Netherlands.
Jeroen VanbrabantADx NeuroSciences Ghent Belgium.
Andrew J BallQuanterix Billerica Massachusetts USA.
Yolande PijnenburgAlzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC Amsterdam the Netherlands.
Afina W LemstraAlzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC Amsterdam the Netherlands.
Wiesje M van der FlierAlzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC Amsterdam the Netherlands.
Erik StoopsADx NeuroSciences Ghent Belgium.
Christophe HirtzIRMB-PPC, INM, Univ Montpellier, CHU Montpellier, INSERM CNRS Montpellier France.
Charlotte E TeunissenNeurochemistry Laboratory Department of Clinical Chemistry Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC Amsterdam the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: We explored what combination of blood-based biomarkers (amyloid beta [Aβ] Methods: We measured the biomarkers with Simoa in two separate cohorts (n = 160 and n = 152). In one cohort, Aβ Results: MS and Simoa Aβ Discussion: A combination of plasma p-tau181, NfL, and GFAP, but not Aβ

Indexed as

amyloid betablood biomarkerglial fibrillary acidic proteinneurofilament lightphosphorylated tau

Identifiers

PMID35603139
PMCPMC9107685

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.