Evidence map›Paper›PMID 35602775›Full record

ArticleCureus2022

Nausea, Vomiting, and Dyspepsia Following Solid Organ Abdominal Transplant.

Simone A Jarrett, Kevin B Lo, Cameron Body, Joyce J Kim, Ziduo Zheng, Suprateek Kundu, Eugene Huang, Arpita Basu, Mary Flynn, Karan A Dietz-Lindo and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Simone A JarrettInternal Medicine, Einstein Medical Center Philadelphia, Philadelphia, USA.
Kevin B LoInternal Medicine, Einstein Medical Center Philadelphia, Philadelphia, USA.
Cameron BodyDepartment of Gastroenterology, Wellstar Atlanta, Atlanta, USA.
Joyce J KimGastroenterology and Hepatology Division, Department of Internal Medicine, University of Michigan, Ann Arbor, USA.
Ziduo ZhengDepartment of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, USA.
Suprateek KunduDepartment of Biostatistics, MD Anderson Cancer Center, Houston, USA.
Eugene HuangDepartment of Biostatistics, Emory University Rollins School of Public Health, Atlanta, USA.
Arpita BasuDivision of Nephrology and Division of Transplant, Emory University School of Medicine, Atlanta, USA.
Mary FlynnDivision of Digestive Diseases, Emory University School of Medicine, Atlanta, USA.
Karan A Dietz-LindoDivision of Digestive Diseases, Emory University School of Medicine, Atlanta, USA.
Nikrad ShahnavazDivision of Digestive Diseases, Emory University School of Medicine, Atlanta, USA.
Jennifer ChristieDivision of Digestive Diseases, Emory University School of Medicine, Atlanta, USA.
Einstein Medical Center Philadelphia · USThe University of Texas MD Anderson Cancer Center · USWellStar Health System · USMichigan Medicine · USUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objective Multiple comorbidities may contribute to high readmission rates post-transplant procedures. In this study, we aimed to assess the rates and factors associated with hospital readmissions for dyspeptic symptoms among transplant patients. Methods This was a retrospective analysis of adult patients who underwent solid organ transplants at our institution. Pregnant patients or those patients with preexisting gastroparesis were excluded from the study. Readmissions associated with the International Classification of Diseases (ICD) codes for nausea/vomiting, weight loss, failure to thrive, abdominal pain, and/or bloating were included. Factors associated with 30-day and frequent readmissions (two or more) were explored. Results A total of 931 patients with solid organ transplants were included; 54% had undergone kidney transplants while 34% were liver transplants. Of note, 30% were readmitted within the first 30 days after discharge following transplant while 32.3% had frequent readmissions. A post-transplant upper endoscopy (EGD) was performed in 34% with food residue discovered in 19% suggesting gastroparesis. However, since only 22% of these patients had a gastric emptying study, only 6% were formally diagnosed with gastroparesis, which was independently associated with both 30-day [odds ratios (OR): 2.58, 95% confidence intervals (CI): 1.42-4.69] and frequent readmissions (OR: 6.71, 95% CI: 3.45-13.10). The presence of pre-transplant diabetes (35%) was significantly associated with a diagnosis of gastroparesis following transplant (OR: 5.17, 95% CI: 2.79-9.57). The use of belatacept (OR: 0.63, 95% CI: 0.42-0.94, p=0.023) was associated with a decrease in the odds of 30-day readmissions. Conclusion A significant number of patients were readmitted due to dyspeptic symptoms after solid organ transplants. Diabetes and gastroparesis were significantly associated with higher odds of readmissions while the use of belatacept appeared to be a protective factor.

Indexed as

dyspepsiagastroparesisnauseasolid organ transplantvomiting

Identifiers

PMID35602775
PMCPMC9119196
OpenAlexW4224274205

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.