ArticlePhysics and imaging in radiation oncology2022
Cone-beam computed tomography-guided online adaptive radiotherapy is feasible for prostate cancer patients.
Article in Physics and imaging in radiation oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed.
- Development of CBCT-Guided Online Adaptive Radiotherapy.Cancers · 2026Review
- Article
- Biologically adaptive radiation oncology in oligometastatic and oligoprogressive disease: MR- and CBCT-guided adaptation, molecular imaging, dose painting, biomarkers, and AI.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- CBCT based online daily adaptive treatment improves target coverage with limited benefit for OAR protection in SBRT prostate cancer.Radiation oncology (London, England) · 2026Article
- Implementation of an AI-Driven Workflow for Daily Dose Reconstruction in Prostate Cancer Radiotherapy.Cancers · 2026Article
- [Daily online adaptive irradiation of bladder tumors with individualized safety margin creation].Magyar onkologia · 2026Article
- Solution for the hot spots in adaptive radiotherapy planning for cervical cancer: a case report and review of literature.Frontiers in oncology · 2026Article
- Few-shot CBCT-based synthetic CT generation with denoising diffusion probabilistic model.Medical physics · 2025Article
- CBCT-Based Online Adaptive, Ultra-Hypofractionated Radiotherapy for Prostate Cancer: First Clinical Experiences.Medicina (Kaunas, Lithuania) · 2025Article
- A cone-beam computed tomography based workflow for online adaptive ultra-hypofractionated radiotherapy of prostate cancer.Physics and imaging in radiation oncology · 2025Article
- Optimizing Workflow for Cone Beam Computed Tomography-Based Online Adaptive Radiation Therapy Toward Reduced Physician Involvement.Advances in radiation oncology · 2025Article
- Pelvic dose accumulation accuracy in a CBCT based online adaptive radiotherapy system.Journal of applied clinical medical physics · 2025Article
- Article
- Assessing population-based to personalized planning strategies for head and neck adaptive radiotherapy.Journal of applied clinical medical physics · 2025Article
- Cone Beam Online Adaptive Radiation Therapy: A Promising Approach for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma?Advances in radiation oncology · 2025Article
- First-in-Men Online Adaptive Robotic Stereotactic Body Radiation Therapy: Toward Ultrahypofractionation for High-Risk Prostate Cancer Patients.Advances in radiation oncology · 2025Article
- Exploration of an adaptive proton therapy strategy using CBCT with the concept of digital twins.Physics in medicine and biology · 2025Article
- Evaluation of artificial intelligence-based autosegmentation for a high-performance cone-beam computed tomography imaging system in the pelvic region.Physics and imaging in radiation oncology · 2025Article
- Clinical implementation of RTT-only CBCT-guided online adaptive focal radiotherapy for bladder cancer.Clinical and translational radiation oncology · 2025Article
- Clinical Implementation of Cone Beam Computed Tomography-Guided Online Adaptive Radiation Therapy in Whole Breast Irradiation.Advances in radiation oncology · 2025Article
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8 authors.
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Abstract
Background and purpose: Studies have shown the potential of cone-beam computed tomography (CBCT)-guided online adaptive radiotherapy (oART) for prostate cancer patients in a simulation environment. The aim of this study was to evaluate the feasibility of the clinical implementation of CBCT-guided oART for prostate cancer patients. Materials and methods: Between February and July 2020, eleven prostate cancer patients were treated with CBCT-guided oART using a fractionation scheme of 20 × 3 Gy to the prostate and 20 × 2.7/3.0 Gy to the seminal vesicles for more advanced stages. The on-couch adaptive workflow consisted of influencer (prostate, seminal vesicles, rectum, bladder) review, target review, scheduled (re-calculated) and adapted (re-optimized) plan generation, an independent QA procedure and treatment delivery. Treatment time, proportion of adapted fractions and reasons for plan adaptation were evaluated. Results: Mean total treatment time (±SD) from CBCT acquisition to end of treatment delivery was 17.5 ± 3.2 min (range: 10.8-28.8 min). In all 220 fractions, the PTV coverage was increased for the adapted plan compared to the scheduled plan. The V60Gy of bladder and rectum were below the constraints (<5% and <3%) for both scheduled and adapted plans in 171 out of 220 fractions and for the adapted plan only in 30 out of 220 fractions. In 19 out of 220 fractions, the V60Gy of the bladder and/or rectum was above the constraint for the adapted plan. Conclusions: The clinical implementation of CBCT-guided oART is feasible for prostate cancer patients. The adaptive workflow is possible within twenty minutes on average with a dedicated team.
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